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Table 4 Univariate and multivariate analysis of factors associated with recurrence in HCC patients (n = 174)

From: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

  RFS
Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
Gender (Female vs. Male) 0.816 0.492–1.352 0.422    
Age, years (≤ 50 vs. > 50) 1.342 0.922–1.953 0.117    
HBsAg (Negative vs. Positive) 2.518 1.225–5.176 0.008* 2.580 1.252–5.305 0.014*
Child-Pugh classification (A vs. B) 1.824 0.799–4.165 0.154    
Serum AFP, ng/ml (≤ 20 vs. > 20) 1.103 0.738–1.648 0.627    
Tumor Number (Single vs. Multiple) 1.333 0.827–2.148 0.229    
Tumor size, cm (≤ 5 vs. > 5) 1.841 1.236–2.740 0.002* 1.530 1.013–2.306 0.043*
Tumor capsule (No/ incomplete vs. Yes) 0.78 0.535–1.136 0.187    
Vascular invasion (N0 vs. Yes) 1.706 0.828–3.515 0.136    
Liver cirrhosis (Absent vs. Present) 1.109 0.669–1.839 0.682    
Differentiation grade (I / II vs. III/IV) 1.481 1.017–2.158 0.036* 1.224 0.823–1.791 0.327
TNM stage (I vs. II/III) 1.479 0.975–2.244 0.06    
KOR (Positive vs. Negative) 0.626 0.516–0.760 < 0.001* 0.669 0.543–0.810 < 0.001*
  1. P-values were obtained from the Cox proportional hazards regression analysis
  2. *Statistical significance was set to P < 0.05