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Table 2 Correlation of KOR protein expression with clinicopathological features in HCC (n = 174)

From: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

Variables Cases KOR protein
High expression (n = 182) Low expression (n = 126) P
Gender
 Female 37 22 15 0.509
 Male 271 160 111
Age, years
 ≤ 50 93 47 46 0.737
 > 50 81 43 38
HBsAg
 Negative 23 13 10 0.621
 Positive 151 77 74
Child-Pugh classificationa
 A 167 81 86 0.770
 B 7 3 4
Serum AFP, ng/ml
 ≤ 20 55 34 21 0.070
 > 20 119 56 63
Tumor Number
 Single 143 75 68 0.682
 Multiple 31 15 16
Tumor size, cm
 ≤ 5 71 47 24 0.002*
 > 5 103 43 60
Tumor capsule
 No/incomplete 77 35 42 0.140
 Yes 97 55 42
Vascular invasion
 No 163 89 74 0.003*
 Yes 11 1 10
Liver cirrhosis
 Absent 32 19 13 0.338
 Present 142 71 71
Differentiation grade
 I / II 102 60 42 0.026*
 III/IV 72 30 42
TNM stage
 I 129 73 56 0.030*
 II/III 45 17 28
  1. The data are reported as number. P-values were obtained from the chi-square test. aNo patient with Child-Pugh class C was found. *Statistical significance was set to P < 0.05