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Table 2 Correlation of KOR protein expression with clinicopathological features in HCC (n = 174)

From: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients

Variables

Cases

KOR protein

High expression (n = 182)

Low expression (n = 126)

P

Gender

 Female

37

22

15

0.509

 Male

271

160

111

Age, years

 ≤ 50

93

47

46

0.737

 > 50

81

43

38

HBsAg

 Negative

23

13

10

0.621

 Positive

151

77

74

Child-Pugh classificationa

 A

167

81

86

0.770

 B

7

3

4

Serum AFP, ng/ml

 ≤ 20

55

34

21

0.070

 > 20

119

56

63

Tumor Number

 Single

143

75

68

0.682

 Multiple

31

15

16

Tumor size, cm

 ≤ 5

71

47

24

0.002*

 > 5

103

43

60

Tumor capsule

 No/incomplete

77

35

42

0.140

 Yes

97

55

42

Vascular invasion

 No

163

89

74

0.003*

 Yes

11

1

10

Liver cirrhosis

 Absent

32

19

13

0.338

 Present

142

71

71

Differentiation grade

 I / II

102

60

42

0.026*

 III/IV

72

30

42

TNM stage

 I

129

73

56

0.030*

 II/III

45

17

28

  1. The data are reported as number. P-values were obtained from the chi-square test. aNo patient with Child-Pugh class C was found. *Statistical significance was set to P < 0.05
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BMC Cancer

ISSN: 1471-2407

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