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Table 1 Characteristics of 97 previous diagnosed de novo acute erythroid/myeloid leukemia patients

From: An analysis of 97 previously diagnosed de novo adult acute erythroid leukemia patients following the 2016 revision to World Health Organization classification

  Total
N = 97
MDS
N = 65
AML
N = 32
P
Characteristics
 Sex, M/F 60/37 46/19 14/18 0.01
 Median age, y(range) 37 (11–75) 39 (11–70) 33 (15–75) 0.044
 Median hemoglobin level, g/L(range) 72 (36–141) 71 (36–141) 73 (41–119) 0.615
 Median WBC, ×109/L(range) 3.5 (0.61–62.9) 3.36 (0.61–44.83) 4.25 (1.21–62.9) 0.201
 Median platelet count, ×109/L(range) 49 (8–480) 49 (9–480) 46 (8–233) 0.441
Cytogenetic results, %
 Normal karyotype 77.8 (70/90) 76.3 (45/59) 80.6 (25/31) 0.635
 Complex karyotype 10 (9/90) 11.9 (7/59) 6.5 (2/31) 0.657
 Monosomy karyotype 5.6 (5/90) 5.1 (3/59) 6.5 (2/31) 1.0
 Intermediate MRC category 87.8 (79/90) 86.4 (51/59) 87.5 (28/32) 1.0
 Unfavorable MRC category 12.2 (11/90) 13.6 (8/59) 9.4 (3/32) 0.804
 Good IPSS category 78.9 (71/90) 78.0 (46/59) 80.6 (25/31) 0.767
 Intermediate IPSS category 10 (9/90) 10.2 (6/59) 9.7 (3/31) 1.0
 Adverse IPSS category 11.1 (10/90) 11.9 (7/59) 9.7 (3/31) 1.0
Molecular mutations, %
NPM1 mutation 19.1 (9/47) 18.2 (6/33) 21.4 (3/14) 1.0
FLT3-ITD mutation 4.3 (3/69) 6.5 (3/46) 4.3 (1/23) 1.0
CEBPA single mutation 6.4 (3/47) 6.3 (2/32) 6.7 (1/15) 0.487
CEBPA double mutation 6.4 (3/47) 3.1 (1/32) 13.3 (2/15) 0.487
DNMT3A R882 mutation 9.1 (3/33) 11.5 (3/26) 0 (0/7) 1.0