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Table 4 Predictive factors on disease-free survival after liver resection

From: Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study

  Univariate analysis Multivariate analysis
  n median survival [mo] HR 95% CI p-value HR 95% CI p-value
Sex
 female 30 10.2 1      
 male 13 7.1 1.062 0.528 - 2.136 0.866    
Age at first liver resection (yr)
 ≤ 50 13 35.5 1      
 > 50 30 7.1 1.552 0.759 - 3.173 0.229    
Occurence of liver metastases
 secondary 30 9.1 1      
 simultaneous 13 7.1 1.309 0.640 - 2.677 0.461    
Major liver resection
 no 30 7.1 1      
 yes 11 31.4 0.558 0.256 1.216 0.142   
Number of liver metastases
 1 26 11.2 1    1   
 > 1 7 4.1 2.490 1.028 - 6.034 0.043 3.747 1.292 - 10.865 0.015
Pathologic margin
 R0 30 10.2 1      
 R1 8 3.1 1.859 0.827 - 4.175 0.133    
 Rx 5 73.1 0.809 0.276 - 2.377 0.700    
Side of primary tumour
 right 26 7.1 1      
 left 17 15.2 0.710 0.367 - 1.374 0.309    
Size of primary tumour (cm)
 ≤ 10 16 18.2 1    1   
 > 10 24 7.1 2.034 0.985 - 4.198 0.055 2.764 1.062 - 7.192 0.037
Secreting primary tumour
 no 15 13.2 1      
 yes 21 9.1 1.008 0.490 - 2.071 0.983    
Chemotherapy after liver resection
 no 35 15.2 1    1   
 yes 8 3.1 2.844 1.193 - 6.777 0.018 2.568 0.936 - 7.043 0.067
Mitotane after liver resection
 no 22 7.1 1      
 yes 21 10.2 0.994 0.517 - 1.912 0.985    
Time to liver metastases [mo]
 > 12 25 18.3 1      
 ≤ 12 18 6.1 1.754 0.895 - 3.436 0.102