Table 4 Predictive factors on disease-free survival after liver resection
From: Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study
Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
n | median survival [mo] | HR | 95% CI | p-value | HR | 95% CI | p-value | |
Sex | ||||||||
female | 30 | 10.2 | 1 | |||||
male | 13 | 7.1 | 1.062 | 0.528 - 2.136 | 0.866 | |||
Age at first liver resection (yr) | ||||||||
≤ 50 | 13 | 35.5 | 1 | |||||
> 50 | 30 | 7.1 | 1.552 | 0.759 - 3.173 | 0.229 | |||
Occurence of liver metastases | ||||||||
secondary | 30 | 9.1 | 1 | |||||
simultaneous | 13 | 7.1 | 1.309 | 0.640 - 2.677 | 0.461 | |||
Major liver resection | ||||||||
no | 30 | 7.1 | 1 | |||||
yes | 11 | 31.4 | 0.558 | 0.256 | 1.216 | 0.142 | ||
Number of liver metastases | ||||||||
1 | 26 | 11.2 | 1 | 1 | ||||
> 1 | 7 | 4.1 | 2.490 | 1.028 - 6.034 | 0.043 | 3.747 | 1.292 - 10.865 | 0.015 |
Pathologic margin | ||||||||
R0 | 30 | 10.2 | 1 | |||||
R1 | 8 | 3.1 | 1.859 | 0.827 - 4.175 | 0.133 | |||
Rx | 5 | 73.1 | 0.809 | 0.276 - 2.377 | 0.700 | |||
Side of primary tumour | ||||||||
right | 26 | 7.1 | 1 | |||||
left | 17 | 15.2 | 0.710 | 0.367 - 1.374 | 0.309 | |||
Size of primary tumour (cm) | ||||||||
≤ 10 | 16 | 18.2 | 1 | 1 | ||||
> 10 | 24 | 7.1 | 2.034 | 0.985 - 4.198 | 0.055 | 2.764 | 1.062 - 7.192 | 0.037 |
Secreting primary tumour | ||||||||
no | 15 | 13.2 | 1 | |||||
yes | 21 | 9.1 | 1.008 | 0.490 - 2.071 | 0.983 | |||
Chemotherapy after liver resection | ||||||||
no | 35 | 15.2 | 1 | 1 | ||||
yes | 8 | 3.1 | 2.844 | 1.193 - 6.777 | 0.018 | 2.568 | 0.936 - 7.043 | 0.067 |
Mitotane after liver resection | ||||||||
no | 22 | 7.1 | 1 | |||||
yes | 21 | 10.2 | 0.994 | 0.517 - 1.912 | 0.985 | |||
Time to liver metastases [mo] | ||||||||
> 12 | 25 | 18.3 | 1 | |||||
≤ 12 | 18 | 6.1 | 1.754 | 0.895 - 3.436 | 0.102 | |||