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Table 1 Potency of EG22 on BRCA2-proficient and mutant Chinese lung cancer cell lines (IC50 μM)

From: A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

 

VC8

VC8-BRCA

V79

BRCA2 status

−

+

+

EG22

0.724 ± 0.146

12.3 ± 1.40

4.77 ± 0.232

ZSM02

0.799 ± 0.162

2.74 ± 0.277

1.76 ± 0.348

ANI

2.99 ± 0.567

>100

>100

TMZ

61.1± 12.3

>800

433.3 ± 55.9

ANI + TMZ

2.30 ± 0.552

83.5 ± 7.45

60.5 ± 10.6

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BMC Cancer

ISSN: 1471-2407

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