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Table 1 Potency of EG22 on BRCA2-proficient and mutant Chinese lung cancer cell lines (IC50 μM)

From: A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

  VC8 VC8-BRCA V79
BRCA2 status + +
EG22 0.724 ± 0.146 12.3 ± 1.40 4.77 ± 0.232
ZSM02 0.799 ± 0.162 2.74 ± 0.277 1.76 ± 0.348
ANI 2.99 ± 0.567 >100 >100
TMZ 61.1± 12.3 >800 433.3 ± 55.9
ANI + TMZ 2.30 ± 0.552 83.5 ± 7.45 60.5 ± 10.6