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Table 3 Circulating calcium levels in control subjects and breast cancer cases expressing inactivating CaSR mutants

From: Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients

SNP ID

Genotype

n

Meana

Rangeb

p-valuec

RS1801725

G/G (AA)

458

9.13 ± 0.51

8.83–9.46

 

G/T (AS)

115

9.25 ± 0.48

9.00–9.56

0.006

T/T (SS)

10

9.48 ± 0.50

9.29–9.75

0.024

RS1801726

C/C (QQ)

506

9.15 ± 0.52

8.86–9.48

 

C/G (QE)

69

9.20 ± 0.41

8.92–9.47

0.51

G/G (EE)

8

9.10 ± 0.69

9.07–9.50

0.75

  1. aMean circulating calcium (mg/dL) from multiple measurements over variable time periods. bThe lowest and highest mean circulating calcium levels for each genotype. cSignificance in the difference in circulating calcium in subjects expressing the wild type receptor to those expressing polymorphic variants at the two SNPs. The p-values were calculated using the Wilcoxon rank sum test from the median with interquartile ranges for each genotype
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BMC Cancer

ISSN: 1471-2407

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