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Table 2 Chemotherapeutical regimens for use during the primary period

From: Randomized controlled trial of S-1 maintenance therapy in metastatic esophagogastric cancer – the multinational MATEO study

Two drug combinations: Three drug combinations:
Cisplatin/Capecitabine EOX/EOF
 • Cisplatin 80 mg/m2, day 1
 • Capecitabine 1000 mg/m2 twice daily on day 1–14
 Each cycle is repeated on day 22.
• Epirubicin 50 mg/m2, day 1
• Oxaliplatin 130 mg/m2, day 1
• Capecitabine 625 mg/m2 twice daily day 1–21 or 5-FU 200 mg/m2/day, continuously day 1–21
Each cycle is repeated on day 22
Cisplatin/S-1 FLOT
 • Cisplatin 75 mg/m2, day 1
 • S-1 25 mg/m2, twice daily day 1–21
 Each cycle is repeated on day 29.
• Docetaxel 50 mg/m2, day 1
• Oxaliplatin 85 mg/m2, day 1
• Leucovorin 200 mg/mg2, day 1
• 5-FU 2600 mg/m2 (24-h infusion), day 1
Each cycle is repeated on day 15
Cisplatin/5-FU  
 • Cisplatin 75 (−100) mg/m2, day 1
 • 5-FU 800 (−1000) mg/m2/day continuously day 1 to 5 or 1000 mg/m2/day cont. day 1–4
 Each cycle is repeated on day 22
FLO  
 • Oxaliplatin 85 mg/m2, day 1
 • Leucovorin 200 mg/m2, day 1
 • 5-FU 2600 mg/m2 (24-h infusion), day 1
 Each cycle is repeated on day 15
Mod. Folfox-6  
 • Oxaliplatin 85 mg/m2, day 1
 • Leucovorin 400 mg/m2, day 1
 • 5-FU 400 mg/m2 (bolus), day 1
 • 5-FU 2400 mg/m2 (46-h infusion), day 1
 Each cycle is repeated on day 15