Table 2 The association between XRCC1 Arg194Trp and Arg399Gln polymorphisms and objective response, OS and PFS
XRCC1 | Objective response | Overall survival | Progression-free survival | ||||||
|---|---|---|---|---|---|---|---|---|---|
Studies(refs.) | Pooled OR | Ph /I 2(%) | Studies(refs.) | Pooled HR | Ph /I 2(%) | Studies(refs.) | Pooled HR | Ph /I 2(%) | |
Arg194Trp | |||||||||
 ArgArg vs. TrpTrp | |||||||||
  All | 7 [13–16, 23, 26, 27] | 0.64(0.44-0.91) | 0.19/31.1 | 3 [23, 26, 31] | 1.19(0.73–1.65) | 0.92/0.0 | 3 [23, 26, 31] | 1.28(0.74–1.82) | 0.92/0.0 |
  Sample size>100 | 6 [13–16, 23, 26] | 0.67(0.46-0.97) | 0.17/35.4 | 3 [23, 26, 31] | 1.19(0.73–1.65) | 0.92/0.0 | 3 [23, 26, 31] | 1.28(0.74–1.82) | 0.92/0.0 |
  Year ≥ 2009 | 5 [13, 14, 23, 26, 27] | 0.65(0.44-0.99) | 0.09/49.8 | 3 [23, 26, 31] | 1.19(0.73–1.65) | 0.92/0.0 | 3 [23, 26, 31] | 1.28(0.74–1.82) | 0.92/0.0 |
 TrpArg vs. TrpTrp | |||||||||
  All | 7 [13–16, 23, 26, 27] | 1.05(0.73–1.51) | 0.35/10.8 | - | - | - | - | - | - |
  Sample size>100 | 6 [13–16, 23, 26] | 1.04(0.71–1.52) | 0.24/25.4 | - | - | - | - | - | - |
  Year ≥ 2009 | 5 [13, 14, 23, 26, 27] | 0.91(0.60–1.39) | 0.56/0.0 | - | - | - | - | - | - |
 ArgArg + TrpArg vs. TrpTrp | |||||||||
  All | 7 [13–16, 23, 26, 27] | 0.79(0.56–1.11) | 0.32/13.9 | 1 [26] | - | - | 1 [26] | - | - |
  Sample size>100 | 6 [13–16, 23, 26] | 0.80(0.57–1.14) | 0.23/27.1 | 1 ([26]) | - | - | 1 [26] | - | - |
  Year ≥ 2009 | 5 [13, 14, 23, 26, 27] | 0.75(0.51–1.10) | 0.26/24.6 | 1 ([26]) | - | - | 1 [26] | - | - |
 ArgArg vs. TrpArg + TrpTrp | |||||||||
  All | 7 [13–16, 23, 26, 27] | 0.55(0.36-0.84) | 0.01/63.0 | 3 [23, 26, 31] | 1.07(0.79–1.35) | 0.79/0.0 | 3 [23, 26, 31] | 0.94(0.72–1.17) | 0.648/0.0 |
  Sample size>100 | 6 [13–16, 23, 26] | 0.60(0.39-0.92) | 0.02/62.7 | 3 [23, 26, 31] | 1.07(0.79–1.35) | 0.79/0.0 | 3 [23, 26, 31] | 0.94(0.72–1.17) | 0.648/0.0 |
  Year ≥ 2009 | 5 [13, 14, 23, 26, 27] | 0.63(0.37–1.05) | 0.02/65.9 | 3 [23, 26, 31] | 1.07(0.79–1.35) | 0.79/0.0 | 3 [23, 26, 31] | 0.94(0.72–1.17) | 0.648/0.0 |
Arg399Gln | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 GlnGln vs. ArgArg | |||||||||
  All | 10 [13–15, 17, 20, 22–24, 26, 27] | 0.77(0.38–1.57) | 0.005/62.0 | 7 [17, 19, 22–24, 28, 31] | 1.15(0.61–1.69) | 0.006/66.6 | 5 [17, 22, 23, 26, 31] | 0.72(0.48-0.97) | 0.136/42.9 |
  Sample size>100 | 8 [13–15, 17, 22–24, 26] | 0.77(0.35–1.73) | 0.002/69.9 | 7 [17, 19, 22–24, 28, 31] | 1.15(0.61–1.69) | 0.006/66.6 | 5 [17, 22, 23, 26, 31] | 0.72(0.48-0.97) | 0.136/42.9 |
  Asian | 9 [13–15, 17, 20, 23, 24, 26, 27] | 0.75(0.33–1.68) | 0.003/66.1 | 4 [17, 23, 24, 31] | 0.86(0.41–1.30) | 0.052/61.2 | 4 [17, 23, 26, 31] | 0.67(0.40-0.94) | 0.106/51.0 |
  Caucasian | 1 [22] | - | - | 3 [19, 22, 28] | 2.29(1.25-3.33) | 0.423/0.0 | 1 [22] | - | - |
  Year ≥ 2009 | 9 [13, 14, 17, 22–24, 26, 27] | 0.83(0.39–1.77) | 0.005/63.5 | 6 [17, 19, 22–24, 31] | 1.06(0.54–1.57) | 0.011/66.2 | 5 [17, 22, 23, 26, 31] | 0.72(0.48-0.97) | 0.136/42.9 |
 GlnArg vs. ArgArg | |||||||||
  All | 10 [13–15, 17, 20, 22–24, 26, 27] | 0.90(0.67–1.21) | 0.053/46.2 | 7 [17, 19, 23–25, 28, 31] | 0.93(0.68–1.18) | 0.003/69.3 | 4 [17, 23, 26, 31] | 0.96(0.79–1.14) | 0.416/0.0 |
  Sample size>100 | 8 [13–15, 17, 22–24, 26] | 0.89(0.63–1.26) | 0.02/57.8 | 7 [17, 19, 23–25, 28, 31] | 0.93(0.68–1.18) | 0.003/69.3 | 4 [17, 23, 26, 31] | 0.96(0.79–1.14) | 0.416/0.0 |
  Asian | 9 [13–15, 17, 20, 23, 24, 26, 27] | 0.90(0.65–1.25) | 0.035/51.8 | 4 [17, 23, 24, 31] | 0.91(0.56–1.27) | 0.003/78.1 | 4 [17, 23, 26, 31] | 0.96(0.79–1.14) | 0.416/0.0 |
  Caucasian | 1 [22] | - | - | 3 [19, 25, 28] | 1.01(0.51–1.51) | 0.057/65.2 | - | - | - |
  Year ≥ 2009 | 9 [13, 14, 17, 22–24, 26, 27] | 0.97(0.79–1.20) | 0.112/38.4 | 5 [17, 19, 23, 24, 31] | 0.97(0.64–1.31) | 0.003/74.7 | 4 [17, 23, 26, 31] | 0.96(0.79–1.14) | 0.416/0.0 |
 GlnGln + GlnArg vs. ArgArg | |||||||||
  All | 13 [13–15, 17–24, 26, 27] | 0.72(0.50–1.04) | 0.000/70.9 | 6 [17, 19, 20, 23, 26, 31] | 0.73(0.50–1.05) | 0.001/72.5 | 4 [17, 23, 26, 31] | 0.94(0.77–1.10) | 0.274/22.8 |
  Sample size>100 | 10 [13–15, 17, 19, 21–24, 26] | 0.78(0.53–1.16) | 0.000/72.5 | 5 [17, 19, 23, 26, 31] | 0.85(0.55–1.15) | 0.02/65.9 | 4 [17, 23, 26, 31] | 0.94(0.77–1.10) | 0.274/22.8 |
  Asian | 11 [13–15, 17, 18, 20, 21, 23, 24, 26, 27] | 0.70(0.46–1.07) | 0.000/75.7 | 5 [17, 20, 23, 26, 31] | 0.65(0.43-0.98) | 0.003/71.7 | 4 [17, 23, 26, 31] | 0.94(0.77–1.10) | 0.274/22.8 |
  Caucasian | 2 [19, 22] | 0.82(0.46–1.44) | 0.966/0.0 | 1 [19] | - | - | - | - | - |
  Year ≥ 2009 | 12 [13, 14, 17–24, 26, 27] | 0.93(0.65–1.34) | 0.004/64.3 | 6 [17, 19, 20, 23, 26, 31] | 0.73(0.50–1.05) | 0.001/72.5 | 4 [17, 23, 26, 31] | 0.94(0.77–1.10) | 0.274/22.8 |
 GlnGln vs. GlnArg + ArgArg | |||||||||
  All | 12 [13–15, 17, 20, 22–24, 26, 27, 29, 30] | 0.85(0.50–1.45) | 0.028/49.0 | 5 [19, 24, 26, 29, 30] | 1.19(0.53–1.84) | 0.01/68.9 | 2 [26, 30] | 0.94(0.37–1.52) | 0.435/0.0 |
  Sample size>100 | 9 [13–15, 17, 22–24, 26, 29] | 0.78(0.43–1.41) | 0.015/58.0 | 4 [19, 24, 26, 29] | 1.44(1.01-1.88) | 0.686/0.0 | 1 [26] | - | - |
  Asian | 10 [13–15, 17, 20, 23, 24, 26, 27, 29] | 0.75(0.41–1.37) | 0.023/53.4 | 3 [24, 26, 29] | 1.40(0.96–1.84) | 0.999/0.0 | 1 [26] | - | - |
  Caucasian | 2 [22, 30] | 1.58(0.42–5.98) | 0.194/40.6 | 2 [19, 30] | 1.43(−1.05–3.91) | 0.058/72.1 | 1 [30] | - | - |
  Year ≥ 2009 | 11 [13, 14, 17, 20, 22–24, 26, 27, 29, 30] | 0.87(0.47–1.62) | 0.038/51.0 | 5 [19, 24, 26, 29, 30] | 1.19(0.53–1.84) | 0.01/68.9 | 2 [26, 30] | 0.94(0.37–1.52) | 0.435/0.0 |