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Table 1 Main characteristics of studies included in this meta-analysis

From: Association between the XRCC1 polymorphisms and clinical outcomes of advanced NSCLC treated with platinum-based chemotherapy: a meta-analysis based on the PRISMA statement

Study Year Country Ethnicity Case No. Genotyping method Stage Treatment Response (Genotype distribution) Outcome SNPs of XRCC1 HWE
XRCC1 Arg399Gln XRCC1 Arg194Trp
CR + PR SD + PD CR + PR SD + PD
GG GA AA GG GA AA CC CT TT CC CT TT
Peng [17] 2014 China Asian 235 PCR-CTTP IIIA-IV 40 41 3 71 74 6 TR/OS/PFS Arg399Gln <0.005
Zhang [23] 2014 China Asian 375 Sequenom MassARRAY IIIA-IV 49 54 24 125 94 29 60 44 23 118 90 41 TR/OS/PFS Arg194Trp Arg399Gln <0.05
Lee [24] 2013 S. Korea Asian 382 Sequenome mass spectrometry-based genotyping assay III-IV 110 64 5 100 75 16 TR/OS Arg399Gln >0.05
Tiseo [30] 2013 Italy Caucasian 93 TaqMan IIIB-IV 14 4 27 2 TR/OS Arg399Gln
Zhao [26] 2013 China Asian 147 TaqMan allelic discrimination assay IIIA-IV 21 24 8 56 31 5 32 20 1 51 35 6 TR/OS/PFS Arg194Trp Arg399Gln >0.05
Li [18] 2012 China Asian 89 PCR-RFLP IIIA-IV 20 6 24 39 TR Arg399Gln
Liao 1[20] 2012 Taiwan Asian 62 SNPstream UHT IIIB-IV 9 9 1 17 22 4 TR/OS Arg399Gln >0.05
Liao 2[20] 2012 Taiwan Asian 45 SNPstream UHT IIIB-IV OS Arg399Gln >0.05
Joerger [22] 2012 Netherlands Caucasian 131 BigDye Terminator Cycle Sequencing Ready Reaction Kit IIIB-IV 17 18 5 34 45 12 TR/OS/PFS Arg399Gln >0.05
Xu [14] 2011 China Asian 130 PCR-RFLP IIIB-IV 30 14 0 36 40 10 12 14 18 42 26 18 TR Arg194Trp Arg399Gln >0.05
Zhou [21] 2011 China Asian 111 PCR-RFLP IV 29 6 42 34 TR/TTP Arg399Gln
Yuan [31] 2010 China Asian 199 PCR-RFLP IIIA-IV OS/PFS Arg194Trp Arg399Gln
Hong [13] 2009 China Asian 164 PCR-RFLP III-IV 26 28 3 44 53 10 19 31 7 54 42 11 TR Arg194Trp Arg399Gln >0.05
Kalikaki [19] 2009 Greece Caucasian 119 PCR-RFLP IIIA-IV 11 26 21 60 TR/OS Arg399Gln
Sun [27] 2009 China Asian 87 3D DNA microarray IV 14 8 1 39 22 3 8 18 5 31 19 6 TR Arg194Trp Arg399Gln >0.05
Yao [29] 2009 China Asian 102 PCR-RFLP IIIB-IV 13 9 32 48 TR/OS Arg399Gln
De las Penas R. [25] 2006 Spain Caucasian 135 allelic discrimination assay IIIB-IV - OS Arg399Gln
Yuan [16] 2006 China Asian 200 PCR-RFLP Advanced        24 38 10 69 46 13 TR Arg194Trp >0.05
Gurubhagavatula [28] 2004 USA Caucasian 103 PCR-RFLP IIIA-IV - OS Arg399Gln -
Wang [15] 2004 China Asian 105 PCR-RFLP IIIB-IV 22 9 2 31 33 8 11 19 3 43 18 11 TR Arg194Trp Arg399Gln >0.05
  1. Footnote: TR treatment response, OS overall survival, PFS progression free survival, CR complete response, PR partial response, SD stable disease, PD progressive disease, SNPs single nucleotide polymorphisms, XRCC1 X-ray repair cross-complementing protein 1, HWE Hardy-Weinberg equilibrium, G = Arg, A = Gln, C = Arg, T = Trp