Table 1 Main characteristics of studies included in this meta-analysis
Study | Year | Country | Ethnicity | Case No. | Genotyping method | Stage | Treatment Response (Genotype distribution) | Outcome | SNPs of XRCC1 | HWE | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
XRCC1 Arg399Gln | XRCC1 Arg194Trp | ||||||||||||||||||||
CRÂ +Â PR | SDÂ +Â PD | CRÂ +Â PR | SDÂ +Â PD | ||||||||||||||||||
GG | GA | AA | GG | GA | AA | CC | CT | TT | CC | CT | TT | ||||||||||
Peng [17] | 2014 | China | Asian | 235 | PCR-CTTP | IIIA-IV | 40 | 41 | 3 | 71 | 74 | 6 | − | − | − | − | − | − | TR/OS/PFS | Arg399Gln | <0.005 |
Zhang [23] | 2014 | China | Asian | 375 | Sequenom MassARRAY | IIIA-IV | 49 | 54 | 24 | 125 | 94 | 29 | 60 | 44 | 23 | 118 | 90 | 41 | TR/OS/PFS | Arg194Trp Arg399Gln | <0.05 |
Lee [24] | 2013 | S. Korea | Asian | 382 | Sequenome mass spectrometry-based genotyping assay | III-IV | 110 | 64 | 5 | 100 | 75 | 16 | − | − | − | − | − | − | TR/OS | Arg399Gln | >0.05 |
Tiseo [30] | 2013 | Italy | Caucasian | 93 | TaqMan | IIIB-IV | 14 | 4 | 27 | 2 | − | − | − | − | − | − | TR/OS | Arg399Gln | − | ||
Zhao [26] | 2013 | China | Asian | 147 | TaqMan allelic discrimination assay | IIIA-IV | 21 | 24 | 8 | 56 | 31 | 5 | 32 | 20 | 1 | 51 | 35 | 6 | TR/OS/PFS | Arg194Trp Arg399Gln | >0.05 |
Li [18] | 2012 | China | Asian | 89 | PCR-RFLP | IIIA-IV | 20 | 6 | 24 | 39 | − | − | − | − | − | − | TR | Arg399Gln | − | ||
Liao 1[20] | 2012 | Taiwan | Asian | 62 | SNPstream UHT | IIIB-IV | 9 | 9 | 1 | 17 | 22 | 4 | − | − | − | − | − | − | TR/OS | Arg399Gln | >0.05 |
Liao 2[20] | 2012 | Taiwan | Asian | 45 | SNPstream UHT | IIIB-IV | − | − | − | − | − | − | − | − | − | − | − | − | OS | Arg399Gln | >0.05 |
Joerger [22] | 2012 | Netherlands | Caucasian | 131 | BigDye Terminator Cycle Sequencing Ready Reaction Kit | IIIB-IV | 17 | 18 | 5 | 34 | 45 | 12 | − | − | − | − | − | − | TR/OS/PFS | Arg399Gln | >0.05 |
Xu [14] | 2011 | China | Asian | 130 | PCR-RFLP | IIIB-IV | 30 | 14 | 0 | 36 | 40 | 10 | 12 | 14 | 18 | 42 | 26 | 18 | TR | Arg194Trp Arg399Gln | >0.05 |
Zhou [21] | 2011 | China | Asian | 111 | PCR-RFLP | IV | 29 | 6 | 42 | 34 | − | − | − | − | − | − | TR/TTP | Arg399Gln | − | ||
Yuan [31] | 2010 | China | Asian | 199 | PCR-RFLP | IIIA-IV | − | − | − | − | − | − | − | − | − | − | − | − | OS/PFS | Arg194Trp Arg399Gln | − |
Hong [13] | 2009 | China | Asian | 164 | PCR-RFLP | III-IV | 26 | 28 | 3 | 44 | 53 | 10 | 19 | 31 | 7 | 54 | 42 | 11 | TR | Arg194Trp Arg399Gln | >0.05 |
Kalikaki [19] | 2009 | Greece | Caucasian | 119 | PCR-RFLP | IIIA-IV | 11 | 26 | 21 | 60 | − | − | − | − | − | − | TR/OS | Arg399Gln | − | ||
Sun [27] | 2009 | China | Asian | 87 | 3D DNA microarray | IV | 14 | 8 | 1 | 39 | 22 | 3 | 8 | 18 | 5 | 31 | 19 | 6 | TR | Arg194Trp Arg399Gln | >0.05 |
Yao [29] | 2009 | China | Asian | 102 | PCR-RFLP | IIIB-IV | 13 | 9 | 32 | 48 | − | − | − | − | − | − | TR/OS | Arg399Gln | − | ||
De las Penas R. [25] | 2006 | Spain | Caucasian | 135 | allelic discrimination assay | IIIB-IV | - | − | − | − | − | − | − | − | − | − | − | − | OS | Arg399Gln | − |
Yuan [16] | 2006 | China | Asian | 200 | PCR-RFLP | Advanced | Â | Â | Â | Â | Â | Â | 24 | 38 | 10 | 69 | 46 | 13 | TR | Arg194Trp | >0.05 |
Gurubhagavatula [28] | 2004 | USA | Caucasian | 103 | PCR-RFLP | IIIA-IV | - | − | − | − | − | − | − | − | − | − | − | − | OS | Arg399Gln | - |
Wang [15] | 2004 | China | Asian | 105 | PCR-RFLP | IIIB-IV | 22 | 9 | 2 | 31 | 33 | 8 | 11 | 19 | 3 | 43 | 18 | 11 | TR | Arg194Trp Arg399Gln | >0.05 |