Skip to main content

Table 4 Cox models for DFS and OS (multivariate analysis)

From: Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

  Multivariate analysis* - DFS Multivariate analysis*– OS
Variable HR 95% CI p HR 95% CI p
GSTT1 (nullvs. Present) 1.67 0.96 2.91 0.071 2.82 1.41 5.64 0.003
RFC1 – AA 1 (reference) 1 (reference)
RFC1 – GA 2.15 1.00 4.65 0.051 1.53 0.57 4.14 0.402
RFC1 – GG 2.64 1.18 5.90 0.018 2.62 0.94 7.31 0.066
Combined genotype groups**         
Group 1 1 (reference) 1 (reference)
Group 2 3.93 1.42 10.86 0.008 3.87 0.92 16.20 0.064
Group 3 6.35 1.82 22.17 0.004 11.53 2.26 58.71 0.003
  1. HR Hazard Ratio, CI Confidence Intervals, DFS Disease free Survival, OS Overall Survival, LN lymph nodes
  2. *multivariate model includes the combination of GSTT1 and RFC1genes adjusted for age, ER/PGR, stage
  3. **group1:GSTT1-present and RFC1-AA;group2: GSTT1-present and RFC1-GA/RFC1-GG or GSTT1-null and RFC1-GA/RFC1-AA
  4. group3: GSTT1-null and RFC1-GG