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Table 4 Cox models for DFS and OS (multivariate analysis)

From: Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

 

Multivariate analysis* - DFS

Multivariate analysis*– OS

Variable

HR

95% CI

p

HR

95% CI

p

GSTT1 (nullvs. Present)

1.67

0.96

2.91

0.071

2.82

1.41

5.64

0.003

RFC1 – AA

1 (reference)

1 (reference)

RFC1 – GA

2.15

1.00

4.65

0.051

1.53

0.57

4.14

0.402

RFC1 – GG

2.64

1.18

5.90

0.018

2.62

0.94

7.31

0.066

Combined genotype groups**

        

Group 1

1 (reference)

1 (reference)

Group 2

3.93

1.42

10.86

0.008

3.87

0.92

16.20

0.064

Group 3

6.35

1.82

22.17

0.004

11.53

2.26

58.71

0.003

  1. HR Hazard Ratio, CI Confidence Intervals, DFS Disease free Survival, OS Overall Survival, LN lymph nodes
  2. *multivariate model includes the combination of GSTT1 and RFC1genes adjusted for age, ER/PGR, stage
  3. **group1:GSTT1-present and RFC1-AA;group2: GSTT1-present and RFC1-GA/RFC1-GG or GSTT1-null and RFC1-GA/RFC1-AA
  4. group3: GSTT1-null and RFC1-GG
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BMC Cancer

ISSN: 1471-2407

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