Skip to main content

Table 2 Comparison of apoptosis induced by DZNep in chondrosarcomas cultured in 2D and 3D cultures

From: Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

  Apoptotic cell fraction p-value (DZNep Vs control) p-value (DZNep 3D Vs DZNep 2D)
Control DZNep
2D 0.73 ± 0.3% 29.6 ± 1.4% 0.001  
3D 21.7 ± 1.4% 86.8 ± 1.7% 0.001 0.001
  1. Chondrosarcoma cells were cultured in monolayer (2D) or embedded in alginate (3D). Then, cells were treated with 1 μM DZNep. Fourteen days later, apoptosis was assayed. Values represent means ± SEM of 3 experiments