Skip to main content

Table 1 Comparison of apoptosis induced by cisplatin in chondrosarcomas cultured in 2D and 3D cultures

From: Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

 

Apoptotic cell fraction

p-value

(cisplatin Vs control)

p-value (cisplatin 3D Vs cisplatin 2D)

Control

Cisplatin

2D

1.8 ± 0.4%

59.4 ± 9.1%

0.009

 

3D

25.8 ± 1.9%

38.8 ± 1.9%

0.02

0.03

  1. Chondrosarcoma cells were cultured in monolayer (2D) or embedded in alginate (3D). Then, cells were treated with 10 μM cisplatin. Three days later, apoptosis was assayed. Values represent means ± SEM of 3 experiments
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us