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Table 1 Comparison of apoptosis induced by cisplatin in chondrosarcomas cultured in 2D and 3D cultures

From: Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

  Apoptotic cell fraction p-value
(cisplatin Vs control)
p-value (cisplatin 3D Vs cisplatin 2D)
Control Cisplatin
2D 1.8 ± 0.4% 59.4 ± 9.1% 0.009  
3D 25.8 ± 1.9% 38.8 ± 1.9% 0.02 0.03
  1. Chondrosarcoma cells were cultured in monolayer (2D) or embedded in alginate (3D). Then, cells were treated with 10 μM cisplatin. Three days later, apoptosis was assayed. Values represent means ± SEM of 3 experiments