JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression

BMC Cancer

Table 2 Associations between JMJD2A, LDHA protein expression and clinicopathological characteristics in NPC

Variable	Cases	JMJD2A expression		P-value	LDHA expression		P-value
Variable	Cases	Low (n = 24)	High (n = 26)	P-value	Low (n = 21)	High (n = 29)	P-value
Gender
Male	22	10	12	0.749	9	13	0.890
Female	28	14	14		12	16
Age(years)
< 50	21	9	12	0.536	7	14	0.291
≥ 50	29	15	14		14	15
Histological type
DNKC	25	11	14	0.571	10	15	0.774
UDC	25	13	12		11	14
T classification
T1-T2	31	20	11	0.003*	18	13	0.003*
T3-T4	19	4	15		3	16
N classification
N0-N1	32	14	18	0.423	13	19	0.793
N2-N3	18	10	8		8	10
M classification
M0	37	21	16	0.037*	19	18	0.024*
M1	13	3	10		2	11
Clinical stage
I-II	24	17	7	0.002*	16	8	0.001*
III-IV	26	7	19		5	21

DNKC differentiated non-keratinizing carcinoma, UDC undifferentiated carcinoma, T tumor size, N lymph node metastasis, M distant metastasis
*P < 0.05 indicates a significant association among the variables (2-tailed)

ISSN: 1471-2407