Fig. 2

PAK1 knockout inhibited intestinal tumour growth and increased spleen weight of APC^∆14/+ mice. PAK1 wild type (WT, n = 20), heterozygous (het, n = 20) and knockout (KO, n = 21) APC^∆14/+ mice were culled at 10 weeks of age. The small intestine and colon/rectum were dissected, and tumour numbers counted (a). The tumour incidence was calculated by dividing the number of mice that developed tumours by the total number of mice used for the experiment and multiplying by 100 (b). Whole blood was taken for full blood cell count. Samples used in a, b and d were from APC^∆14/+ mice on a PAK1 WT, het or KO background. Samples used in c were from both APC^+/+ and APC^∆14/+ mice on PAK1 WT, het or KO backgrounds. *, p < 0.05 compared to PAK1 WT APC^∆14/+ mice