Skip to main content

Table 1 Comparison of the predicted upstream regulatory pathways in ESCC

From: African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks

GSE77861 GSE17351 GSE33810 GSE20347
Gene z-score -log(p) Gene z-score -log(p) Gene z-score -log(p) Gene z-score -log(p)
 NFE2L2 3.8 7.5 NUPR1 4.7 10.1 mir-8 2.6 1.2 RABL6 5.8 26.7
 MEK 2.7 1.2 CLDN7 3.9 7.9 let-7 2.6 0.3 FOXM1 4.4 14.2
 LDL 2.8 0.5 MYOCD 3.8 6.0 LYN 2.4 0.6 IgG complex 3.7 21.9
CTNNB1 2.6 1.6 NR3C1 3.7 4.2 IL10RA 2.3 1.0 MITF 3.5 15.8
RABL6 2.5 2.1 IRGM1 3.5 7.0 TRIM24 2.4 0.1 FOXO1 3.4 11.3
FOXM1 2.4 1.2 BNIP3L 3.4 8.2 miR-1-3p 2.2 0.8 RARA 3.3 16.2
 CBX5 2.3 2.4 RBL2 3.2 4.8 IFI16 2.2 0.4 TLR7 3.3 4.2
 ANGPT2 2.3 2.3 TP53 3.2 21.1 ZBTB16 2.2 2.0 PRL 3.3 8.1
 PLIN5 2.2 2.2 IL1RN 3.1 4.3 miR-10 2.2 0.4 IFNL1 3.2 10.0
 ANXA7 2.2 2.4 SRF 3.0 5.7 CDKN2A 2.1 0.1 TGFB1 3.2 46.3
TP53 −3.1 18.4 CSF2 −5.6 9.3 ERBB2 −3.2 8.2 TP53 −5.3 38.7
 IL13 −3.0 0.7 RABL6 −4.1 8.9 SHH −3.1 7.8 NUPR1 −4.4 19.5
CDKN2A −3.0 2.6 SPP1 −4.1 5.3 IGFBP2 −3.1 7.5 SPDEF −4.0 8.7
CD28 −2.8 2.0 EGFR −3.8 14.0 TGFB3 −2.9 7.5 KDM5B −3.4 12.6
 EHF −2.5 2.3 ERK1/2 −3.8 9.2 ERG −2.9 7.0 HSF1 −3.3 6.7
CLDN7 −2.4 3.9 EGF −3.7 9.9 CCTNB1 −2.7 7.1 CDKN1A −3.3 9.5
let-7 −2.2 0.5 HGF −3.6 17.1 CREB −2.6 1.7 CLDN7 −3.1 6.7
 ESRRA −2.2 1.4 TNF −3.4 3.9 WNT1 −2.5 0.6 BTK −2.9 5.0
 TCF3 −2.0 0 E2F1 −3.4 7.9 CCND1 −2.5 2.9 WISP2 −2.9 8.6
 FGFR1 −2.0 0.8 FN1 −3.4 4.7 ERG2 −2.5 0.9 E2F6 −2.8 4.3
GSE29001 GSE33426 GSE45670 GSE23400
Gene z-score -log(p) Gene z-score -log(p) Gene z-score -log(p) Gene z-score -log(p)
RABL6 5.8 25.2 TGFB1 7.7 42.9 TNF 5.3 24.0 CSF2 5.0 14.4
 HGF 5.7 39.5 TNF 7.2 15.1 ERBB2 4.9 21.3 RABL6 4.7 19.7
VEGF 5.3 32.7 VEGF 7.0 15.0 CSF 4.2 4.8 VEGF 4.4 32.3
FOXM1 5.0 19.4 HGF 6.9 22.0 EGFR 3.9 13.6 HGF 4.2 38.8
CSF2 5.0 30.7 ESR1 6.9 42.0 IFNL1 3.8 5.8 FOXM1 4.0 16.0
E2F1 4.6 28.1 EGF 6.5 12.0 IFNG 3.7 21.3 ESR1 3.9 31.1
TBX2 4.4 13.0 CSF2 6.5 14.0 CCND1 3.7 18.5 ERBB2 3.7 56.4
 E2F group 4.2 15.8 CTNNB1 6.3 13.0 IL1A 3.6 15.5 FN1 3.7 7.5
 IFNA1 3.7 6.4 SMARCA4 6.2 11.0 RABL6 3.6 5.1 TBX2 3.6 12.2
IFNL1 3.6 13.0 IFNG 5.9 15.0 OSM 3.5 15.6 EGF 3.4 32.6
NUPR1 −6.2 15.6 let-7 −6.0 19.0 GATA4 −4.8 11.6 TP53 −5.2 53.0
let-7 −5.0 17.0 CD3 −5.1 15.0 IL10RA −4.3 7.4 CDKN2A −4.3 10.5
KDM5B −4.5 10.7 SPDEF −4.2 8.0 MYOCD −3.9 11.2 let-7 −3.9 16.0
IRGM −4.5 14.8 KDM5B −4.1 7.5 IL1RN −3.6 8.1 RB1 −3.8 17.7
TP53 −4.2 54.2 IRGM1 −4.0 9.0 IRGM1 −3.5 6.5 NR3C1 −3.5 7.9
SPDEF −4.1 10.2 TRIM24 −4.9 4.0 HAND2 −3.3 5.7 SPDEF −3.4 8.5
RBL2 −4.0 13.7 RB1 −3.9 14.0 SRF −3.3 11.1 PPARG −3.3 13.0
BNIP3L −4.0 17.3 RBL2 −3.9 7.2 ACKR2 −3.2 5.3 let-7a-5p −3.3 4.3
CDKN2A −3.9 7.3 IL1RN −3.8 2.2 PTEN −3.2 5.0 IRGM1 −3.2 7.2
TRIM24 −3.8 18.2 CD28 −3.6 8.2 POU5F1 −3.0 2.4 CR1L −3.1 8.9
  1. The upstream regulatory pathways represented more than one study in the meta-analysis indicated in bold