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Table 4 Specificity of criteria for BRCA1/2 testing

From: Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

Test criteria

Specificitya

BC < 40 years

(403/427) 94.4%

BC < 50 years

(321/427) 75.2%

BC < 60 years

(205/427) 48%

TNBC

(397/422) 94.1%

Fulfilling NBCG criteria for diagnostic testing

(297/427) 69.5%

Fulfilling NBCG criteria for predictive testing

(378/427) 89%

  1. aSpecificity is calculated only for Cohort 1, OUH-U
  2. BC Breast cancer
  3. TNBC Triple negative breast cancer
  4. NBCG Norwegian breast cancer group
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BMC Cancer

ISSN: 1471-2407

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