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Table 4 Specificity of criteria for BRCA1/2 testing

From: Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

Test criteria Specificitya
BC < 40 years (403/427) 94.4%
BC < 50 years (321/427) 75.2%
BC < 60 years (205/427) 48%
TNBC (397/422) 94.1%
Fulfilling NBCG criteria for diagnostic testing (297/427) 69.5%
Fulfilling NBCG criteria for predictive testing (378/427) 89%
  1. aSpecificity is calculated only for Cohort 1, OUH-U
  2. BC Breast cancer
  3. TNBC Triple negative breast cancer
  4. NBCG Norwegian breast cancer group