Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

BMC Cancer

Table 3 Sensitivity of criteria for testing to identify BRCA1/2 carriers

Test criteria	BRCA1/2 mutation carriers (n = 38^a)
BC <40 years	12 (31.6%)
BC <50 years	28 (73.7%)
BC <60 years	34 (89.5%)
TNBC	13 (34.2%)
Fulfilling stringent NBCG criteria for testing	32 (84.2%)
Fulfilling ASCO guidelines for testing	34 (89.5%)
Fulfilling NICE guidelines for testing	17 (44.7%)
Fulfilling NCCN criteria for testing	32 (88.9%)
Family history fulfilling NBCG criteria for predictive testing before index person contracted BC	14 (36.8%)

^aThe four women belonging to families where a mutation had already been identified were excluded from this analysis
BC Breast cancer
TNBC Triple Negative Breast Cancer
NBCG Norwegian Breast Cancer Group
ASCO American Society of Clinical Oncology
NICE National Institute for Health and Care Excellence
NCCN The National Comprehensive Cancer Network

ISSN: 1471-2407