Table 1 Inclusion and exclusion criteria

 - Patients aged 18 to 85 years

 - First HER2 positive breast cancer, confirmed histologically

 - WHO Performance status ≤1

 - Completed chemo-radiotherapy

 - Normal renal function (creatinine clearance ≥60 ml.min-1)

 - Normal heart function with LVEF ≥50% (As assessed by echocardiography dating from less than 3 months previously)

 - Normal liver function (normal ASAT and ALAT)

 - Certificate of non-contraindication to the practice of physical activity

 - Active contraception or menopaused

- HER2 negative Breast cancer

- Patients with metastases

- Heart failure (LVEF ≤50%)

- Resting oxygen saturation (SaO₂) ≤ 92%

- Autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis)

- Symptomatic osteoarthritis, cardiovascular disease (angina or uncontrolled hypertension) or lung disease (chronic obstructive pulmonary disease)

- Patients suffering from malnutrition (body mass index <18 kg.m⁻²) or weight loss of >10% during the previous 3 months

- Patients with psychiatric or cognitive disorders deemed unsuitable for physical activity

- Pregnant or breastfeeding patients