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Table 3 Differential expression of effector genes in ovarian and fallopian tube cells

From: Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

 

Ovarian cells

Fallopian tube cells

Effector genes

Overall

P-value

BNT

BOT

NSMT

SMT

CCL

OV_ST

Overall P-value

STIC

FT_ST

Difference in medians against normal cells (P-value)

Difference in medians against normal cells (P-value)

CDH1

<0.0005†

6.872 (0.030*)

7.070 (0.004*)

6.819 (0.001*)

6.479 (0.001*)

6.592 (0.002*)

3.552 (0.672)

0.050†

7.546 (0.458)

4.940 (0.114)

CDH3

<0.0005†

1.395 (0.102)

1.911 (0.006*)

1.370 (0.024*)

2.019 (0.001*)

1.120 (0.216)

2.323 (0.007*)

0.038†

5.370 (0.458)

5.112 (0.114)

CDH11

<0.0005†

−0.917 (1.000)

−2.679 (0.003*)

−2.953 (0.001*)

−2.444 (0.001*)

−9.627 (0.001*)

−0.198 (1.000)

0.445

−2.481 (0.458)

−0.272 (0.800)

CRB3

<0.0005†

4.786 (1.000)

5.302 (0.003*)

5.178 (0.001*)

4.652 (0.001*)

4.884 (0.001*)

−5.034 (1.000)

0.057

3.731 (0.458)

1.485 (0.114)

LLGL2

<0.0005†

3.633 (0.102)

4.472 (0.003*)

4.538 (0.001*)

2.882 (0.001*)

3.221 (0.001*)

1.654 (0.007*)

0.018†

4.495 (0.458)

2.745 (0.114)

OCLN

<0.0005†

1.231 (1.000)

1.014 (0.006*)

0.829 (0.096)

0.838 (0.003*)

1.590 (0.012*)

−2.429 (0.010*)

0.034†

3.096 (0.458)

1.215 (0.114)

CLDN7

<0.0005†

4.978 (0.984)

5.689 (0.003*)

5.336 (0.001*)

5.203 (0.001*)

4.896 (0.001*)

0.398 (1.000)

0.018†

6.995 (0.458)

3.327 (0.114)

SFN

<0.0005†

0.266 (1.000)

4.168 (0.003*)

4.638 (0.001*)

3.022 (0.001*)

4.412 (0.001*)

0.231 (1.000)

0.445

−0.184 (1.000)

−1.170 (0.800)

PPL

<0.0005†

3.186 (0.012*)

4.017 (0.003*)

2.941 (0.001*)

2.600 (0.001*)

3.099 (0.001*)

1.322 (1.000)

0.018†

4.336 (0.114)

3.684 (0.114)

EVA1

<0.0005†

11.177 (0.012*)

11.728 (0.003*)

11.459 (0.001*)

11.927 (0.001*)

11.146 (0.001*)

10.105 (0.003*)

0.018†

5.809 (0.114)

5.374 (0.114)

EpCAM

<0.0005†

6.759 (0.060)

7.272 (0.003*)

7.383 (0.001*)

6.692 (0.001*)

6.810 (0.001*)

3.405 (0.003*)

0.026†

5.720 (0.114)

1.208 (0.228)

TSPAN1

<0.0005†

7.922 (0.012*)

9.214 (0.003*)

8.662 (0.001*)

6.263 (0.001*)

7.030 (0.001*)

3.565 (0.003*)

0.018†

6.783 (0.114)

5.594 (0.114)

PATJ

<0.0005†

1.605 (0.234)

2.106 (0.006*)

1.841 (0.001*)

1.210 (0.001*)

1.202 (0.006*)

0.233 (0.924)

0.018†

3.229 (0.114)

2.521 (0.114)

SCEL

<0.0005†

1.685 (1.000)

15.068 (0.003*)

12.210 (0.001*)

13.000 (0.001*)

13.054 (0.001*)

10.820 (0.036*)

0.943

−0.230 (1.000)

−8.010 (1.000)

SH3YL1

<0.0005†

2.466 (0.012*)

2.778 (0.003*)

2.285 (0.001*)

1.681 (0.001*)

0.840 (0.024*)

2.126 (0.003*)

0.030†

3.300 (0.114)

3.064 (0.114)

PKP3

<0.0005†

2.905 (1.000)

4.467 (0.003*)

4.135 (0.001*)

3.401 (0.001*)

4.066 (0.001*)

0.935 (1.000)

0.057

4.463 (0.114)

0.151 (1.000)

TMEM30B

<0.0005†

5.936 (0.012*)

6.352 (0.003*)

6.083 (0.001*)

5.493 (0.001*)

5.362 (0.004*)

3.300 (0.084)

0.024†

7.019 (0.114)

5.539 (0.114)

MAL2

<0.0005†

1.066 (1.000)

1.895 (0.003*)

1.577 (0.001*)

1.753 (0.001*)

1.507 (0.006*)

−2.284 (1.000)

0.095

1.447 (0.458)

−1.279 (0.800)

MUC1

<0.0005†

3.849 (0.234)

5.906 (0.003*)

5.480 (0.001*)

4.651 (0.001*)

2.027 (0.036*)

1.138 (0.270)

0.018†

5.808 (0.114)

3.414 (0.114)

MUC16

<0.0005†

0.370 (1.000)

6.820 (0.048*)

5.030 (0.246)

5.531 (0.001*)

3.535 (0.006*)

0.630 (1.000)

0.055

3.044 (0.114)

0.130 (1.000)

HE4

<0.0005†

1.890 (1.000)

6.100 (0.108)

5.400 (0.006*)

5.681 (0.001*)

1.359 (1.000)

−1.090 (1.000)

0.018†

8.767 (0.114)

5.247 (0.114)

  1. †significant at the 0.05 level by Kruskal Wallis test
  2. *significant at the 0.05 level by Mann-Whitney test (corrected using the Bonferroni method for multiple comparisons)