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Table 3 Differential expression of effector genes in ovarian and fallopian tube cells

From: Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

  Ovarian cells Fallopian tube cells
Effector genes Overall
P-value
BNT BOT NSMT SMT CCL OV_ST Overall P-value STIC FT_ST
Difference in medians against normal cells (P-value) Difference in medians against normal cells (P-value)
CDH1 <0.0005 6.872 (0.030*) 7.070 (0.004*) 6.819 (0.001*) 6.479 (0.001*) 6.592 (0.002*) 3.552 (0.672) 0.050 7.546 (0.458) 4.940 (0.114)
CDH3 <0.0005 1.395 (0.102) 1.911 (0.006*) 1.370 (0.024*) 2.019 (0.001*) 1.120 (0.216) 2.323 (0.007*) 0.038 5.370 (0.458) 5.112 (0.114)
CDH11 <0.0005 −0.917 (1.000) −2.679 (0.003*) −2.953 (0.001*) −2.444 (0.001*) −9.627 (0.001*) −0.198 (1.000) 0.445 −2.481 (0.458) −0.272 (0.800)
CRB3 <0.0005 4.786 (1.000) 5.302 (0.003*) 5.178 (0.001*) 4.652 (0.001*) 4.884 (0.001*) −5.034 (1.000) 0.057 3.731 (0.458) 1.485 (0.114)
LLGL2 <0.0005 3.633 (0.102) 4.472 (0.003*) 4.538 (0.001*) 2.882 (0.001*) 3.221 (0.001*) 1.654 (0.007*) 0.018 4.495 (0.458) 2.745 (0.114)
OCLN <0.0005 1.231 (1.000) 1.014 (0.006*) 0.829 (0.096) 0.838 (0.003*) 1.590 (0.012*) −2.429 (0.010*) 0.034 3.096 (0.458) 1.215 (0.114)
CLDN7 <0.0005 4.978 (0.984) 5.689 (0.003*) 5.336 (0.001*) 5.203 (0.001*) 4.896 (0.001*) 0.398 (1.000) 0.018 6.995 (0.458) 3.327 (0.114)
SFN <0.0005 0.266 (1.000) 4.168 (0.003*) 4.638 (0.001*) 3.022 (0.001*) 4.412 (0.001*) 0.231 (1.000) 0.445 −0.184 (1.000) −1.170 (0.800)
PPL <0.0005 3.186 (0.012*) 4.017 (0.003*) 2.941 (0.001*) 2.600 (0.001*) 3.099 (0.001*) 1.322 (1.000) 0.018 4.336 (0.114) 3.684 (0.114)
EVA1 <0.0005 11.177 (0.012*) 11.728 (0.003*) 11.459 (0.001*) 11.927 (0.001*) 11.146 (0.001*) 10.105 (0.003*) 0.018 5.809 (0.114) 5.374 (0.114)
EpCAM <0.0005 6.759 (0.060) 7.272 (0.003*) 7.383 (0.001*) 6.692 (0.001*) 6.810 (0.001*) 3.405 (0.003*) 0.026 5.720 (0.114) 1.208 (0.228)
TSPAN1 <0.0005 7.922 (0.012*) 9.214 (0.003*) 8.662 (0.001*) 6.263 (0.001*) 7.030 (0.001*) 3.565 (0.003*) 0.018 6.783 (0.114) 5.594 (0.114)
PATJ <0.0005 1.605 (0.234) 2.106 (0.006*) 1.841 (0.001*) 1.210 (0.001*) 1.202 (0.006*) 0.233 (0.924) 0.018 3.229 (0.114) 2.521 (0.114)
SCEL <0.0005 1.685 (1.000) 15.068 (0.003*) 12.210 (0.001*) 13.000 (0.001*) 13.054 (0.001*) 10.820 (0.036*) 0.943 −0.230 (1.000) −8.010 (1.000)
SH3YL1 <0.0005 2.466 (0.012*) 2.778 (0.003*) 2.285 (0.001*) 1.681 (0.001*) 0.840 (0.024*) 2.126 (0.003*) 0.030 3.300 (0.114) 3.064 (0.114)
PKP3 <0.0005 2.905 (1.000) 4.467 (0.003*) 4.135 (0.001*) 3.401 (0.001*) 4.066 (0.001*) 0.935 (1.000) 0.057 4.463 (0.114) 0.151 (1.000)
TMEM30B <0.0005 5.936 (0.012*) 6.352 (0.003*) 6.083 (0.001*) 5.493 (0.001*) 5.362 (0.004*) 3.300 (0.084) 0.024 7.019 (0.114) 5.539 (0.114)
MAL2 <0.0005 1.066 (1.000) 1.895 (0.003*) 1.577 (0.001*) 1.753 (0.001*) 1.507 (0.006*) −2.284 (1.000) 0.095 1.447 (0.458) −1.279 (0.800)
MUC1 <0.0005 3.849 (0.234) 5.906 (0.003*) 5.480 (0.001*) 4.651 (0.001*) 2.027 (0.036*) 1.138 (0.270) 0.018 5.808 (0.114) 3.414 (0.114)
MUC16 <0.0005 0.370 (1.000) 6.820 (0.048*) 5.030 (0.246) 5.531 (0.001*) 3.535 (0.006*) 0.630 (1.000) 0.055 3.044 (0.114) 0.130 (1.000)
HE4 <0.0005 1.890 (1.000) 6.100 (0.108) 5.400 (0.006*) 5.681 (0.001*) 1.359 (1.000) −1.090 (1.000) 0.018 8.767 (0.114) 5.247 (0.114)
  1. significant at the 0.05 level by Kruskal Wallis test
  2. *significant at the 0.05 level by Mann-Whitney test (corrected using the Bonferroni method for multiple comparisons)