Table 4 Enriched MsigDB Hallmark genesets

HALLMARK Epithelial mesenchymal transition

CD59, CDH11, CDH2, COL1A1, COL1A2, COL4A2, COL5A1, COL6A3, CTGF, CYR61, DAB2, DPYSL3, EDIL3, EMP3, ENO2, FAP, FBN1, FBN2, FERMT2, GEM, GJA1, GREM1, LGALS1, LOX, MMP14, MMP2, PCOLCE, PCOLCE2, PLAUR, PLOD1, PMP22, POSTN, SERPINE1, SERPINE2, SLIT2, SPARC, SPOCK1, TGFB1, TIMP1, VCAN, VIM, WNT5A

HALLMARK Estrogen response late

ALDH3A2, ASS1, CDH1, CELSR2, LLGL2, LSR, MAPK13, PLXNB1, RAPGEFL1, SCNN1A, SLC22A5, SLC27A2, ST14, TOB1, TRIM29

HALLMARK Apical junction

AKT3, CDH1, CDH11, CLDN7, FBN1, GRB7, JAM3, JUP, MAPK13, MMP2, MPZL2, PVRL3, SLIT2, VCAN

HALLMARK UV response dn

AKT3, COL1A1, COL1A2, CYR61, DAB2, FZD2, GJA1, HAS2, KCNMA1, MAP1B, PMP22, SERPINE1

HALLMARK Estrogen response early

AQP3, CELSR2, CLDN7, ELF3, GJA1, KRT15, PMAIP1, RAPGEFL1, SCNN1A, SLC22A5, SLC27A2, TOB1, WWC1

HALLMARK Hypoxia

AKAP12, CHST2, COL5A1, CTGF, CYR61, ENO2, ETS1, HMOX1, KDELR3, LOX, PLAUR, SERPINE1, SRPX

HALLMARK Inflammatory response

CD70, CHST2, EMP3, FZD5, HAS2, HRH1, MMP14, PLAUR, SERPINE1, TIMP1

HALLMARK KRAS signaling up

AKAP12, EPB41L3, ETS1, GFPT2, GNG11, JUP, MAP7, MPZL2, PLAUR, TMEM158, TRIB2

HALLMARK Angiogenesis

JAG2, POSTN, TIMP1, VCAN

HALLMARK Complement

CD59, COL4A2, CTSD, MMP14, PLAUR, SERPINE1, TIMP1, TIMP2, ZEB1

HALLMARK Myogenesis

COL1A1, COL4A2, COL6A3, ERBB3, MEF2C, NCAM1, PDLIM7, SPARC, TGFB1

HALLMARK TGF beta signaling

BCAR3, CDH1, SERPINE1, SMURF2, TGFB1