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Table 1 Serum-VEGF, serum-bFGF and urinary-bFGF levels at diagnosis, according to patient and tumour characteristics

From: Prognostic impact of blood and urinary angiogenic factor levels at diagnosis and during treatment in patients with osteosarcoma: a prospective study

  Serum VEGF (pg/mL) Serum bFGF (pg/mL) Urinary bFGF (ng/g creatinine)
N Median [Q1-Q3]a P value b N Median [Q1-Q3]a P value b N Median [Q1-Q3]a P value b
All 246 428 [274–685]   242 4.3 [3–13]   129 5.2 [2.7–10.4]  
Gender    0.94    0.10    0.30
 Male 136 432 [286–675]   133 5 [3–14]   70 4.5 [2.4–9.6]  
 Female 110 427 [252–686]   109 4 [3–11]   59 5.6 [3.1–10.9]  
Age    0.65    0.07    0.03
  < 13 years 71 466 [223–692]   71 7 [3–18]   36 7.5 [4.8–12.9]  
 13–18 years 106 399 [271–686]   104 4 [3–13]   59 4.1 [2.2–8.9]  
  > 18 years 69 440 [327–642]   67 3 [3–10]   34 5.3 [1.9–11.4]  
Tumour size    0.003    0.24    0.28
  < 10 cm 110 391 [222–567]   108 5 [3–12]   59 4.9 [2.1–9.6]  
  ≥ 10 cm 121 504 [308–738]   119 3 [3–13]   62 5.3 [2.9–11.6]  
Initial stage c    0.64    0.16    0.17
 Localized 164 431 [258–689]   162 4 [3–11]   92 5176 [2.4–9.2]  
 Doubtful lesions 40 418 [335–711]   39 7 [3–15]   21 4.9 [3.3–12.2]  
 Metastases 39 396 [274–621]   38 3 [3–7]   15 9.6 [3.5–17.1]  
Histologic subtype    0.36    0.57    0.46
 Osteoblastic 154 435 [303–735]   152 5 [3–13]   82 5.3 [2.8–10.8]  
 Fibroblastic 10 399 [205–512]   11 7 [3–13]   2 2.6 [1.8–3.3]  
 Chondroblastic 40 461 [280–610]   38 4 [3–11]   26 5.5 [3.5–11.4]  
 Telangiectasic 7 283 [178–692]   7 3 [3–3]   4 5.3 [4–77.3]  
 Other 25 365 [241–484]   24 4 [3–14]   13 3.1 [1.8–7.9]  
Alkaline phosphatase    0.11    0.21    0.33
  < 1.25 x ULN 137 404 [252–644]   135 5 [3–11]   74 4.9 [2.5–9.6]  
  ≥ 1.25 x ULN 70 472 [305–736]   69 3 [3–13]   40 6.1 [3–13.6]  
Histological response d    0.92    0.40    0.44
 Good 138 435 [283–732]   137 5 [3–13]   85 5.1 [2.9–10.2]  
 Poor 76 429 [314–647]   74 4 [3–11]   31 4.1 [2.1–8.9]  
  1. a[Q1-Q3]: inter-quartile range
  2. bKruskal-Wallis test comparing the distributions between the different subsets
  3. cLung metastases on CT were defined by ≥1 nodule >10 mm, and/or ≥2 nodules from 5 to 9 mm, and/or ≥5 well limited nodules <5 mm. Other types of lesion were considered as doubtful lesions
  4. dResults by quartile of the distributions are available in Additional file 5 Table-S3