Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder

Table 1 Association of PKCα and NF-κB p65 expression with clinicopathologic characteristics of the bladder cancer patients

Parameters	Group	No. of cases	P-value
Parameters	Group	No. of cases	PKCα	NF-κB p65
Gender	Male	17 (56.7%)	0.214	0.453
Age (years)	≥60	19 (63.3%)	0.371	0.284
Histological grade	High grade	21 (70%)	< 0.01**	< 0.01**
Muscle invasion	Positive	20 (66.7%)	<0.01**	<0.01**
Distant metastases	Positive	4 (13.3%)	0.124	0.073
Lymphatic invasion	Positive	6 (20%)	<0.05*	< 0.05*

PKCα and p65 expressions were measured by IHC staining, PKCα or p65 positive cell percentages per HPF were counted and statistically compared between two groups. Student’s T test was used to conduct the statistical analysis. *P < 0.05, **P < 0.01

ISSN: 1471-2407