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1.
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Histologically proven adenocarcinoma of the esophagus or adenocarcinoma of the esophagogastric junction type I-II according to Siewert’s classification, clinical stages IIB-IIIC (T3/T4 and/or N+; M0) according to UICC, 7th edition
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2.
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Male
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3.
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Age between 18 and 75 years
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4.
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Resectable stage according to discussion in the local multidisciplinary tumor board (MDT) of the participating centers and patient medically fit for multimodality therapy (ECOG performance status at least 1 or better, no severe impairment of cardiac, renal, hepatic, endocrine, bone marrow and cerebral functions)
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5.
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Planned abdomino-thoracic esophagectomy with gastric pull-up and intrathoracic or cervical anastomosis
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6.
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Cognitive ability of the patient to understand the perioperative program and to participate actively [40, 41]
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