| |
Grade (number of cycles)
|
Patients
|
|---|
| |
1
|
2
|
3
|
4
|
Number
|
%
|
|---|
|
Alkaline phosphatase increased
|
6
| | | |
5
|
21%
|
|
Dysphagia
|
2
|
2
|
1
| |
5
|
21%
|
|
Dyspnea
|
5
|
3
|
2
| |
5
|
21%
|
|
Hypoalbuminemia
|
3
|
1
|
1
| |
5
|
21%
|
|
Dehydration
|
3
|
5
|
1
| |
7
|
29%
|
|
Fever
|
8
| | | |
7
|
29%
|
|
Hypokalemia
|
11
|
1
|
4
|
2
|
7
|
29%
|
|
Transaminases increased
|
11
| | | |
7
|
29%
|
|
Hypertriglyceridemia
|
7
|
1
|
1
| |
8
|
33%
|
|
Peripheral sensory neuropathy
|
8
|
3
| | |
8
|
33%
|
|
Vomiting
|
7
|
1
|
4
| |
8
|
33%
|
|
Anorexia
|
7
|
4
| | |
9
|
38%
|
|
Urinary tract infection
|
1
|
6
|
2
| |
9
|
38%
|
|
Diarrhea
|
8
|
6
|
1
| |
10
|
42%
|
|
Hyperglycemia
|
18
|
6
|
2
| |
10
|
42%
|
|
Hypomagnesemia
|
23
|
6
| | |
10
|
42%
|
|
Mucositis oral
|
10
|
10
|
2
| |
11
|
46%
|
|
White blood cell decreased
|
14
|
14
|
29
|
3
|
12
|
50%
|
|
Nausea
|
17
|
4
|
3
| |
13
|
54%
|
|
Pain
|
7
| | | |
13
|
54%
|
|
Alopecia
|
8
|
12
| | |
14
|
58%
|
|
Fatigue
|
14
|
14
|
1
| |
15
|
63%
|
|
Anemia
|
21
|
45
|
15
| |
20
|
83%
|
|
Platelet count decreased
|
32
|
26
|
14
|
14
|
20
|
83%
|
|
Neutrophil count decreased
|
8
|
19
|
26
|
20
|
21
|
88%
|
- Toxicities by grade seen in >20% of patients deemed possibly, probably, or definitely related in all patients eligible for toxicity evaluation. Under grade, this is listed as: Total Number of Cycles. Under Patients, this is listed as the: Total Number of Patients for any grade. There were 24 patients who received at least 1 dose of treatment and were part of the toxicity evaluation. A patient may be counted only once for each grade of toxicity but may appear under more than one grade for each toxicity
