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Table 2 Results of univariate analysis for possible independent variables associated with death and EFS

From: What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

Variables

EFS

LF

5-year CI

HR (95% CI)

p

5-year CI

HR (95% CI)

p

All patients

62.1%

-

-

6.9%

-

-

Age group

  ≤ 15 years

68.0%

1.00

 

4.6%

1.00

 

  > 15 years

47.6%

2.00 (0.91–4.41)

0.087

13.8%

3.11 (0.44–22.1)

0.257

Sex

 Male

64.0%

1.00

 

9.1%

1.00

 

 Female

58.6%

1.30 (0.60–2.83)

0.513

4.8%

0.58 (0.06–5.53)

0.575

Risk group

 Low

73.7%

1.00

 

5.6%

1.00

 

 High

48.2%

1.74 (0.80–3.80)

0.163

8.3%

1.33 (0.19–9.41)

0.779

Tumor size

  ≤ 8 cm

61.1%

1.00

 

--

--

--

  > 8 cm

58.1%

1.07 (0.41–2.76)

0.892

--

--

--

Necrosis Index

  ≤ 95%

60.7%

1.38 (0.54–3.57)

0.503

5.6%

0.41 (0.04–4.52)

0.466

  > 95%

71.3%

1.00

 

10.5%

1.00

 

LDH

  ≥ 1.5 x ULN

51.3%

1.11 (0.44–2.77)

0.832

15.4%

6.04 (0.55–66.7)

0.142

  < 1.5 x ULN

63.1%

1.00

 

2.4%

1.00

 

Pelvic location

 Yes

41.1%

1.47 (0.55–3.90)

0.440

--

--

--

 No

66.7%

1.00

 

--

--

--

Radiation dose

-

0.99 (0.98–1.01)

0.560

-

0.98 (0.86–1.12)

0.796

  1. EFS event-free survival, LF local failure, CI cumulative incidence, HR hazard ratio; 95% CI, 95% confidence interval, LDH lactate dehydrogenase, ULN upper limit of normal