Table 1 Change in BCL2 family member mRNA levels in venetoclax-resistant cells relative to parental cells. Gene expression data were analyzed using Rosetta Resolver software comparing each venetoclax-resistant cell line to its untreated parental line. Genes/probe sets with > 1.5-fold change relative to parental and meeting a 5% False Discovery Rate were considered significant. Zero signifies no significant change from baseline
From: Potential mechanisms of resistance to venetoclax and strategies to circumvent it
| Â | Cell lines | |||||||
|---|---|---|---|---|---|---|---|---|
Primary Sequence Name | Protein Name | OCI-Ly1 199R | SC-1 199R | HBL1 199R | U2932 199R | RS4;11 199R | HBL2 199R | Granta-519 199R |
BCL2 | BCL-2 | -2.20 | 1.25 | 0.00 | -3.35 | 0.00 | -13.11 | 0.00 |
BCL2L1 | BCL-XL | 0.00 | 14.88 | 0.00 | -2.24 | 0.00 | 0.00 | 0.00 |
MCL1 | MCL-1 | 2.20 | 1.91 | 0.00 | -1.89 | 0.00 | -1.71 | 0.00 |
BCL2A1 | BCL-A1 | -6.13 | 0.00 | 0.00 | 0.00 | 0.00 | 2.19 | 0.00 |
BCL2L2 | BCL-W | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
BAX | BAX | -1.83 | 0.00 | -2.43 | 0.00 | -3.50 | 0.00 | 0.00 |
BAK1 | BAK | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
BID | BID | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
BCL2L11 | BIM | -3.33 | -3.22 | -16.70 | 0.00 | 0.00 | 0.00 | 0.00 |
PMAIP1 | NOXA | -2.54 | -1.50 | -2.19 | -1.65 | 0.00 | -3.16 | 0.00 |
BBC3 | PUMA | -1.64 | -2.08 | 0.00 | 3.49 | 0.00 | 0.00 | 0.00 |
BAD | BAD | 1.34 | 0.00 | 2.40 | 0.00 | 0.00 | 0.00 | 0.00 |