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Table 1 Change in BCL2 family member mRNA levels in venetoclax-resistant cells relative to parental cells. Gene expression data were analyzed using Rosetta Resolver software comparing each venetoclax-resistant cell line to its untreated parental line. Genes/probe sets with > 1.5-fold change relative to parental and meeting a 5% False Discovery Rate were considered significant. Zero signifies no significant change from baseline

From: Potential mechanisms of resistance to venetoclax and strategies to circumvent it

  Cell lines
Primary Sequence Name Protein Name OCI-Ly1 199R SC-1 199R HBL1 199R U2932 199R RS4;11 199R HBL2 199R Granta-519 199R
BCL2 BCL-2 -2.20 1.25 0.00 -3.35 0.00 -13.11 0.00
BCL2L1 BCL-XL 0.00 14.88 0.00 -2.24 0.00 0.00 0.00
MCL1 MCL-1 2.20 1.91 0.00 -1.89 0.00 -1.71 0.00
BCL2A1 BCL-A1 -6.13 0.00 0.00 0.00 0.00 2.19 0.00
BCL2L2 BCL-W 0.00 0.00 0.00 0.00 0.00 0.00 0.00
BAX BAX -1.83 0.00 -2.43 0.00 -3.50 0.00 0.00
BAK1 BAK 0.00 0.00 0.00 0.00 0.00 0.00 0.00
BID BID 0.00 0.00 0.00 0.00 0.00 0.00 0.00
BCL2L11 BIM -3.33 -3.22 -16.70 0.00 0.00 0.00 0.00
PMAIP1 NOXA -2.54 -1.50 -2.19 -1.65 0.00 -3.16 0.00
BBC3 PUMA -1.64 -2.08 0.00 3.49 0.00 0.00 0.00
BAD BAD 1.34 0.00 2.40 0.00 0.00 0.00 0.00