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Table 6 Studies on BRAF mutation status in colorectal cancer patients

From: The prognostic significance of KRAS and BRAF mutation status in Korean colorectal cancer patients

Reference (year) Country BRAF mutation % (n) BRAF mutation type (%) Methods Prognostic value Comments
Pai et al. (2012) [36] USA 11.0 (20) V600E (100) real-time PCR Significant Stage I-IV proficient DNA mismatch repair
Kadowaki et al. (2015) [37] Japan 4.9 (40) V600E (80) PCR combined with restriction enzyme digestion Significant Stage I-III independent of MSI status
Chen et al. (2014) [38] China 4.2 (9) V600E (88.9) direct sequencing Significant Stage I-IV
Siraj et al. (2014) [39] Saudi Arabia 2.5 (19) V600E (89.5) direct sequencing No prognostic significance Stage I-IV
Ahn et al. (2014) [40] Korea 15.9 (26) V600E (100) PNA clamp real-time PCR Significant Stage I-IV
Kim et al. (2014) [41] Korea 9.6 (13) N/A direct sequencing Significant Stage III-IV
Yaeger et al. (2014) [42] USA 5 (92) V600E (96.7) mass spectrometry-based assay Significant Metastatic colorectal cancers
Eklof et al. (2013) [43] Sweden 17.9 (35)
13.2 (54)
V600E (100) allelic discrimination assay Significant No prognostic significance Stage I-IV two different cohorts
Renaud et al. (2015) [44] France 10.6 (19) V600E (100) direct sequencing Significant Metachronous lung metastasis
de Cuba et al. (2015) [45] Netherlands 51.0 (73) V600E (100) high resolution melting and sequencing Significant Stage II and III microsatellite instable colon cancers
Foltran et al. (2015) [46] Italy 5.2 (10) V600E (100) pyrosequencing Significant Metastatic colorectal cancers
Tsai et al. (2015) [47] Taiwan 18.6 (11) V600E (100) direct sequencing Significant Stage I-IV early-onset colorectal cancers
Saridaki et al. (2013) [48] Greece 8.2 (41) V600E (100) real-time PCR Significant Metastatic colorectal cancers
Kalady et al. (2012) [49] USA 11.7 (56) V600E (98.2) direct sequencing Significant Stage I-IV
Farina-Sarasqueta et al. (2010) [50] Netherlands 19.9 (59) V600E (100) real-time PCR Significant Stage II and III independently of disease stage and therapy.
Present case Korea 4.0 (44) V600E (97.7) direct sequencing Significant Stage I-IV Significant prognostic implications through all stages