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Fig. 1 | BMC Cancer

Fig. 1

From: Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated 18F–Fluorodeoxyglucose (18F–FDG) positron emission tomography/magnetic resonance imaging (PET/MRI); The REMAP study

Fig. 1

Illustrating the sites of action of the targeted chemotherapies in renal cell carcinoma. The cell proliferation and angiogenisis cell-signalling pathways are up-regulated in malignancy and can be targeted at the level of the receptors (Pazopinib, Sunitinib), agonist (Bevacizumab) or downstream signalling pathways (Temsirolimus, Everolimus). VEGF: Vascular endothelial growth factor, PDGF: Platelet derived growth factor, mTOR: mammalian target of rapamycin, PI3K: phosphatidylinositol 3-kinase, AKT: protein kinase B, ERK: Extracellular signal-regulated kinase

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BMC Cancer

ISSN: 1471-2407

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