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Table 2 Cox regression for BCR and distant metastasis with LVI and other parameters as covariate

From: Impact of lymphovascular invasion on lymph node metastasis for patients undergoing radical prostatectomy with negative resection margin

 

BCR

Distant metastasis

Univariate

Multivariate

  

Univariate

Multivariate

  

p-value

HR

95% CI

p-value

p-value

HR

95% CI

p-value

Age (years)

 

0.001*

1.001

0.990–1.012

0.855

0.048*

1.023

0.992–1.055

0.149

Initial PSA (ng/mL)

≥20

<0.001*

2.230

1.867–2.662

<0.001*

<0.001*

1.495

0.950–2.353

0.082

Pathologic T stage

 

3

<0.001*

1.522

1.253–1.849

<0.001*

0.103

0.704

0.409–1.212

0.205

 

4

<0.001*

1.707

1.094–2.664

0.019*

<0.001*

2.399

1.026–5.611

0.043*

Pathologic Gleason score

 

7

<0.001*

1.953

1.521–2.508

<0.001*

<0.001*

1.123

0.566–2.229

0.741

 

≥8

<0.001*

3.233

2.474–4.224

<0.001*

<0.001*

3.284

1.670–6.454

0.001*

PSM

 

<0.001*

2.125

1.775–2.543

<0.001*

0.005*

1.317

0.819–2.118

0.256

LVI

 

<0.001*

1.352

1.045–1.749

0.022*

<0.001*

1.738

1.024–2.950

0.040*

Lymph node metastasis

 

<0.001*

1.459

1.035–2.056

0.031*

<0.001*

5.083

2.954–8.749

<0.001*

  1. LVI: lymphovascular invasion; PSM: positive surgical margin; PSA: prostate-specific antigen; NHT: neoadjuvant hormone therapy; HR: hazard ratio; CI: confidence interval
  2. *statistically significant at p < 0.05
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BMC Cancer

ISSN: 1471-2407

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