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Table 2 Cox regression for BCR and distant metastasis with LVI and other parameters as covariate

From: Impact of lymphovascular invasion on lymph node metastasis for patients undergoing radical prostatectomy with negative resection margin

  BCR Distant metastasis
Univariate Multivariate    Univariate Multivariate   
p-value HR 95% CI p-value p-value HR 95% CI p-value
Age (years)   0.001* 1.001 0.990–1.012 0.855 0.048* 1.023 0.992–1.055 0.149
Initial PSA (ng/mL) ≥20 <0.001* 2.230 1.867–2.662 <0.001* <0.001* 1.495 0.950–2.353 0.082
Pathologic T stage
  3 <0.001* 1.522 1.253–1.849 <0.001* 0.103 0.704 0.409–1.212 0.205
  4 <0.001* 1.707 1.094–2.664 0.019* <0.001* 2.399 1.026–5.611 0.043*
Pathologic Gleason score
  7 <0.001* 1.953 1.521–2.508 <0.001* <0.001* 1.123 0.566–2.229 0.741
  ≥8 <0.001* 3.233 2.474–4.224 <0.001* <0.001* 3.284 1.670–6.454 0.001*
PSM   <0.001* 2.125 1.775–2.543 <0.001* 0.005* 1.317 0.819–2.118 0.256
LVI   <0.001* 1.352 1.045–1.749 0.022* <0.001* 1.738 1.024–2.950 0.040*
Lymph node metastasis   <0.001* 1.459 1.035–2.056 0.031* <0.001* 5.083 2.954–8.749 <0.001*
  1. LVI: lymphovascular invasion; PSM: positive surgical margin; PSA: prostate-specific antigen; NHT: neoadjuvant hormone therapy; HR: hazard ratio; CI: confidence interval
  2. *statistically significant at p < 0.05