Table 2 Multivariate logistic regression analysis of factors predictive of vascular invasion in patients with positive seral HbsAg
Variables | Odds ratio | 95% CI | P value |
|---|---|---|---|
Risk of vascular invasion | |||
Age (>50 years vs < =50 years) | 0.68 | 0.44–1.04 | 0.078 |
Alpha-fetoprotein (> 20 ng/ml vs < = 20 ng/ml) | 2.51 | 1.59–3.96 | <0.01* |
Tumor number (Multiple vs Single) | 2.18 | 1.04–4.55 | 0.038* |
Diameter (> 3 cm vs < = 3 cm) | 1.73 | 1.04–2.88 | 0.035* |
Edmonson grading (Grades III/IV vs Grades I/II) | 2.48 | 1.21–5.05 | 0.013* |
Tumor capsule (Incomplete/absent vs Complete) | 2.17 | 1.25–3.77 | 0.006* |
Seral HBeAg (Positive vs Negative) | 1.83 | 1.10–3.03 | 0.019* |
Seral HBV DNA load (> 50 IU/ml vs < = 50 IU/ml) | 1.68 | 1.06–2.65 | 0.027* |
Risk of microscopic vascular invasion | |||
Alpha-fetoprotein (> 20 ng/ml vs < = 20 ng/ml) | 2.59 | 1.65–4.05 | <0.01* |
Tumor number (Multiple vs Single) | 2.21 | 1.09–4.51 | 0.028* |
Diameter (> 3 cm vs < = 3 cm) | 1.58 | 0.96–2.61 | 0.074 |
Edmonson grading (Grades III/IV vs Grades I/II) | 2.24 | 1.11–4.54 | 0.024* |
Tumor capsule (Incomplete/absent vs Complete) | 2.04 | 1.18–3.51 | 0.011* |
Seral HBeAg (Positive vs Negative) | 1.59 | 0.98–2.57 | 0.059 |
Seral HBV DNA load (> 50 IU/ml vs < = 50 IU/ml) | 1.76 | 1.12–2.76 | 0.013* |
Risk of portal vein tumor thrombus | |||
DCP (>100 mAU/ml vs < = 100 mAU/ml) | 2.90 | 1.17–7.12 | 0.022* |
Tumor diameter (>3 cm vs < =3 cm) | 8.86 | 2.67–29.39 | <0.01* |
Tumor capsule (Incomplete/absence vs Complete) | 3.59 | 1.56–8.25 | 0.003* |
Seral HBeAg (Positive vs Negative) | 1.67 | 1.01–2.75 | 0.046* |
Anti-virus treatment (Yes vs No) | 0.59 | 0.33–1.05 | 0.075 |