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Table 3 Classifier Performance

From: A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells

  Demographics only Demographics plus genes
Number of subjects (N) 115 (NC:57, CA:58) 115 (NC:57, CA:58)
Demographic variable used 3: gender, age and pack-years 3: gender, age and pack-years
Picked Gene Features 0 E2F1 ERCC5 XRCC1 GPX1 TP63.2 GSTP1 CDKN1A TP53.2 ERCC4.2 RB1 ERCC5.2 KEAP1.2 ERCC1.2
AUC based on 50 MI* 68.3% (95%R CI: 63.3%–73.1%) 97.5% (95%R CI: 96.0%–98.9%)
Classification Accuracy based on 50 MI* 65.5% (95% CI: 56.8%–74.1%) 93.0% (95% CI: 88.4%–97.7%)
PPV* 64.8% (95% CI: 52.9%–76.6%) 93.1% (95% CI: 86.6%–99.6%)
NPV* 66.3% (95% CI: 53.6%–79.0%) 93.0% (95% CI: 86.4%–99.6%)
Sensitivity* 69.2% (95% CI: 57.4%–81.1%) 93.1% (95% CI: 86.6%–99.6%)
Specificity* 61.6% (95% CI: 49.0%–74.2%) 92.9% (95% CI: 86.3%–99.5%)