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Table 3 Classifier Performance

From: A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells

 

Demographics only

Demographics plus genes

Number of subjects (N)

115 (NC:57, CA:58)

115 (NC:57, CA:58)

Demographic variable used

3: gender, age and pack-years

3: gender, age and pack-years

Picked Gene Features

0

E2F1 ERCC5 XRCC1 GPX1 TP63.2 GSTP1 CDKN1A TP53.2 ERCC4.2 RB1 ERCC5.2 KEAP1.2 ERCC1.2

AUC based on 50 MI*

68.3% (95%R CI: 63.3%–73.1%)

97.5% (95%R CI: 96.0%–98.9%)

Classification Accuracy based on 50 MI*

65.5% (95% CI: 56.8%–74.1%)

93.0% (95% CI: 88.4%–97.7%)

PPV*

64.8% (95% CI: 52.9%–76.6%)

93.1% (95% CI: 86.6%–99.6%)

NPV*

66.3% (95% CI: 53.6%–79.0%)

93.0% (95% CI: 86.4%–99.6%)

Sensitivity*

69.2% (95% CI: 57.4%–81.1%)

93.1% (95% CI: 86.6%–99.6%)

Specificity*

61.6% (95% CI: 49.0%–74.2%)

92.9% (95% CI: 86.3%–99.5%)