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Table 1 Test characteristics and costs of the diagnostic instruments for response evaluation. In the base-case analysis, trial-reported test characteristics were used

From: Cost-effectiveness of response evaluation after chemoradiation in patients with advanced oropharyngeal cancer using 18F–FDG-PET-CT and/or diffusion-weighted MRI

 

Trial-reported test characteristics

Test characteristic based on literature

Costs (Euros)

Sensitivity [95% CI]

Specificity [95% CI]

Positive predictive value [95% CI]

Negative predictive value [95% CI]

Sensitivity

Specificity

EUA

60 [14.7–94.7]

100 [91.4–100.0]

100.0 [29.2–100.0]

95.3 [84.2–99.4]

*

*

468

PET-CT

75 [19.4–99.4]

83 [67.9–92.8]

30.0 [6.7–65.2]

97.1 [85.1–99.9]

79.9a

87.5a

1067

DW-MRI

60 [14.7–94.7]

95 [83.5–99.4]

60.0 [14.7–94.7]

95.1 [83.5–99.4]

89.0b

86.0b

246

Combined PET-CT and DW-MRI

100 [39.8–100.0]

93 [80.1–98.5]

57.1 [18.4–90.1]

100.0 [90.7–100.0]

*

*

1313

  1. *Test characteristics for this diagnostic instrument are not reported in the literature
  2. aBased on the systematic review of Gupta et al. (2011) [7]
  3. bBased on the study of Vaid et al. (2017) [8]