Fig. 5

Genomic location of significantly differentially methylated CpGs. The percentage of hypermethylated and hypomethylated CpGs located in each genomic feature (1st exon, 3′ untranslated region (UTR), 5’UTR, enhancer, intergenic, intron, CpG island, CpG island shore, CpG island shelf, transcription start site (TSS, a window 1500 bp upstream of the TSS) and transcription termination site (TTS)). Probes may be located in more than one genomic feature e.g. CpG islands often overlap transcription start sites