Table 1 Correlation of Six1 expression in cytoplasm to histopathological parameters
Parameter | Six1 expression in malignant tissue | Six1 expression in benign tissue | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Number | No | Weak | Strong | p-value | Number | No | Weak | Strong | p-value | |
Total | 137 | 50 (36,5%) | 66 (48,2%) | 21 (15,3%) | 105 | 91 (86,7%) | 14 (13,3%) | 0 | <0,0001 | |
Age | ||||||||||
< Median | 68 (49,6%) | 26 (34,8%) | 31 | 11 | 0,844 | 47 (44,8%) | 38 (80,9%) | 9 (19,1%) | 0 | 0,253 |
≥ Median | 69 (50,4%) | 24 (34,8%) | 35 (50,7%) | 10 (14,5%) | 58 (55,2%) | 53 (91, 4%) | 5 (8,6%) | 0 | ||
Sexa | 0,591 | 0,902 | ||||||||
Male | 74 (56,5%) | 27 (36,5%) | 32 (43, 2%) | 15 (20,3%) | 56 (53,3%) | 49 (87,5%) | (12,5%) | 0 | ||
Female | 57 (43,5%) | 19 (33,3%) | 32 (56,01%) | 6 (10,5%) | 45 (46,7%) | 39 (85,7%) | 6 (14,3%) | 0 | ||
Tumor sizeb | 1,000 | 0,428 | ||||||||
pT1 | 2 (1,5%) | 1 (50,0%) | 1 (50,0%) | 0 | 2 (1,9%) | 2 (100%) | 0 | 0 | ||
pT2 | 9 (6,7%) | 3 (33,3%) | 5 (55,5%) | 1 (11,1%) | 8 (7,6%) | 7 (87,5%) | 1 (12,5%) | 0 | ||
pT3 | 121 (89,6%) | 42 (34,7%) | 59 (48,8%) | 20 (16,5%) | 90 (85,7%) | 79 (87,8%) | 11 (12,2%) | 0 | ||
pT4 | 3 (2,2%) | 2 (66,7%) | 1 (33,3%) | 0 | 3 (2,9%) | 3 (100%) | 0 | 0 | ||
Lymph node metastasisc | 0,290 | 0,959 | ||||||||
N0 | 38 (27,9%) | 4 (10,5%) | 19 (50,0%) | 15 (39,5%) | 31 (29,5%) | 28 (90,3%) | 3 (9,7%) | 0 | ||
N1 | 98 (72,1%) | 34 (34,7%) | 47 (48,0%) | 17 (17,3%) | 74 (70,5%) | 63 (85,1%) | 11 (14,9%) | 0 | ||
Grading | 0,950 | 0,715 | ||||||||
G1 | 1 (0,7%) | 0 | 1 (100,0%) | 0 | 1 (1,0%) | 1 (100%) | 0 | 0 | ||
G2 | 59 (43,1%) | 21 (35,6%) | 28 (47,5%) | 10 (16,9%) | 44 (41,9%) | 38 (86,4%) | 6 (13,6%) | 0 | ||
G3 | 54 (39,4%) | 18 (33,3%) | 28 (51,2%) | 8 (14,8%) | 45 (42,9%) | 38 (84,4%) | 7 (15,6%) | 0 | ||
Gx | 23 (14,4%) | 11 (47,8%) | 9 (39,1%) | 3 (13,0%) | 15 (14,3%) | 14 (93,3%) | 1 (6,7%) | 0 | ||