Table 2 Associations between ABCG2 expression and clinical parameters in patients with clear cell RCC
Parameters | Value | ABCG2(−) | ABCG2(+) | ABCG2(++) | P |
|---|---|---|---|---|---|
Gender | Female | 16 (28%) | 17 (33%) | 4 (36%) | 0.510 |
Male | 41 (72%) | 35 (67%) | 7 (64%) | ||
Age at surgery (years) | <60 | 4172%) | 33 (63%) | 4 (36%) | 0.054 |
≥60 | 16 (28%) | 19 (37%) | 7 (64%) | ||
Symptoms on first diagnosis | Negative | 36 (63%) | 33 (63%) | 4 (36%) | 0.351 |
Positive | 21 (37%) | 19 (37%) | 7 (64%) | ||
pT | T1a | 23 (40%) | 13 (25%) | 1 (9%) | 0.180 |
T1b | 22 (39%) | 28 (54%) | 5 (45%) | ||
T2 | 9 (16%) | 6 (12%) | 3 (27%) | ||
T3 | 3 (5%) | 5 (10%) | 2 (18%) | ||
Regional lymph node metastasis | Negative | 56 (98%) | 51 (98%) | 9 (82%) | 0.103 |
Positive | 1 (2%) | 1 (2%) | 2 (18%) | ||
Distant metastasis on first diagnosis | Negative | 54 (95%) | 40 (77%) | 7 (64%) | 0.001* |
Positive | 3 (5%) | 12 (23%) | 4 (36%) | ||
Fuhrman grade | 1 | 14 (25%) | 4 (8%) | 0 (0%) | 0.014* |
2 | 31 (54%) | 35 (67%) | 4 (36%) | ||
3 | 9 (16%) | 11 (21%) | 5 (45%) | ||
4 | 3 (5%) | 2 (4%) | 2 (18%) | ||
Five-year survival | Alive | 53 (93%) | 40 (77%) | 3 (27%) | <0.001* |
Deceased | 4 (7%) | 12 (23%) | 8 (73%) | ||
Surgery type | Radical Nephrectomy | 2 (4%) | 4 (8%) | 0 (0%) | 0.441 |
Partial Nephrectomy | 55 (96%) | 48 (92%) | 11 (100%) |