Fig. 5

PTEN is the target gene of miR-181a. a Diagram of the miR-181a putative binding sites and corresponding mutant sites in the 3′-UTR of PTEN. b Effects of miR-181a on the expression of PTEN 3′-UTR-containing reporter genes. ** vs inhibitor NC or mimics NC, p < 0.01. c and d Protein expression of PTEN in HCC cells after transfection with miR-181a mimic or inhibitor. e The expression of PTEN in clinical samples with high or low level of miR-181a. mut, mutant; HCC, hepatocellular carcinoma. ** vs high 181a group, p < 0.01