Table 5 Statistically significant DNA alterations specific for either CD133+ or CD133−/EpCAM+ cell fractions from human colon biopsies. Number of patients refers to the number in each group (n = 20) who displayed the alteration
Chr location | CNV | No patients CD133 (20) | No patients EpCAM (20) | No genes | Examples of genes in the region |
|---|---|---|---|---|---|
CD133 | |||||
1q42.12 | Del | 7 | 7 | 7 | LEFTY1/2, PYCR2, ACBD3 |
8p11.22 | Del | 5 | 5 | 2 | ADAM5P, ADAM3A |
12q13.13 - q14.1 | Del | 15 | 8 | 195 | HOTAIR, GDF11, ERBB3, CDK2, CD63, PTGES3, MIR1228 |
EpCAM | |||||
8q24.3 | Del | 7 | 8 | 27 | NAPRT, MAPK15, SCRIB, PUF60, MIR661, SHARPIN |
11q12.2 - q13.3 | Del | 9 | 9 | 247 | SYT7, MIR1908, MIR612, MIR192, MIR194–2, VEGFB, MALAT1, BAD, FOSL1, RELA |
11q12.3 | Amp | 7 | 5 | 4 | SLC22A9/10/24/25 |
11q13.4 | Del | 6 | 8 | 5 | PDE2A, MIR139, ARAP1, STARD10, ATG16L2 |
11q23.3 | Del | 9 | 8 | 12 | BCL9L, UPK2, FOXR1, TRAPPC4 |
17p13.2 | Del | 5 | 8 | 12 | PFN1, INCA1, KIF1C |
17q21.2 | Amp | 6 | 11 | 39 | Keratins and keratin-associated proteins |