Table 1 Laboratory abnormalities
All Grades n (%) | Grade 1 n (%) | Grade 2 n (%) | Grade 3/4 n (%) | p value | ||
|---|---|---|---|---|---|---|
White blood cell count decreased | pretreatment | 2 (3) | 2 (3) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 10 (13) | 4 (5) | 6 (8) | 0 (0) | 0.10 | |
First cycle | 44 (56) | 12 (15) | 27 (34) | 5 (6) | <0.01 | |
Neutrophil count decreased | pretreatment | 1 (1) | 1 (1) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 4 (5) | 4 (5) | 0 (0) | 0 (0) | 0.56 | |
First cycle | 33 (42) | 12 (15) | 18 (23) | 3 (4) | <0.01 | |
Lymphocyte count decreased | pretreatment | 22 (28) | 13 (16) | 7 (9) | 2 (3) | |
0-2 week of first cycle | 40 (51) | 11 (14) | 8 (10) | 11 (14) | <0.01 | |
First cycle | 46 (58) | 18 (23) | 12 (15) | 16 (20) | <0.01 | |
Hemoglobin decreased | pretreatment | 57 (72) | 34 (43) | 15 (19) | 8 (10) | |
0-2 week of first cycle | 52 (67) | 31 (39) | 18 (23) | 3 (4) | 0.30 | |
First cycle | 67 (85) | 24 (30) | 28 (35) | 15 (19) | <0.01 | |
Platelet count decreased | pretreatment | 9 (11) | 9 (11) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 45 (57) | 35 (44) | 6 (8) | 4 (5) | <0.01 | |
First cycle | 69 (87) | 33 (42) | 20 (25) | 16 (21) | <0.01 | |
Creatinine increased | pretreatment | 29 (36) | 26 (33) | 2 (3) | 1 (1) | |
0-2 week of first cycle | 46 (58) | 42 (53) | 4 (5) | 0 (0) | 0.04 | |
First cycle | 46 (58) | 41 (52) | 4 (5) | 1 (1) | 0.02 | |
Aspartate aminotransferase increased | pretreatment | 12 (15) | 12 (15) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 42 (53) | 34 (43) | 6 (8) | 2 (3) | <0.01 | |
First cycle | 58 (73) | 47 (59) | 7 (9) | 4 (5) | <0.01 | |
Alanine aminotransferase increased | pretreatment | 16 (20) | 16 (20) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 33 (42) | 28 (35) | 4 (5) | 1 (1) | <0.01 | |
First cycle | 55 (70) | 45 (57) | 5 (6) | 5 (6) | <0.01 | |
Hypoalbuminemia | pretreatment | 48 (61) | 28 (35) | 18 (23) | 2 (3) | |
0-2 week of first cycle | 69 (87) | 33 (42) | 30 (38) | 6 (8) | <0.01 | |
First cycle | 75 (95) | 27 (34) | 38 (48) | 10 (13) | <0.01 | |
Blood bilirubin increased | pretreatment | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
0-2 week of first cycle | 3 (4) | 3 (4) | 0 (0) | 0 (0) | 0.36 | |
First cycle | 6 (8) | 5 (6) | 0 (0) | 1 (1) | 0.02 | |
Amylase increased | pretreatment | 19 (24) | 16 (20) | 3 (4) | 0 (0) | |
0-2 week of first cycle | 29 (37) | 19 (24) | 8 (10) | 2 (3) | 0.03 | |
First cycle | 42 (53) | 20 (25) | 11 (14) | 11 (14) | <0.01 |