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Fig. 3 | BMC Cancer

Fig. 3

From: The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

Fig. 3

High dose MK2206 inhibits glioma migration and invasion. a Number of cells invaded through matrigel after 16 h in the presence of 1 μM, 5 μM, or 10 μM MK2206. Columns represent means, ±SD (n = 3), * = p < 0.05. b Percentage of scratch area remaining compared to 0 h. Columns represent means, ±SD (n = 10 replicates), * = p < 0.05. c Area of spheroid outgrowth. Spheroids were treated with 1 μM MK and 4 Gy irradiation and plated in regular culture plates. Data points represent means, ±SD, (n = 8 replicates), * = p < 0.05

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BMC Cancer

ISSN: 1471-2407

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