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Table 2 EGFR Gene mutation status

From: Central nervous system progression in advanced non–small cell lung cancer patients with EGFR mutations in response to first-line treatment with two EGFR-TKIs, gefitinib and erlotinib: a comparative study

Exons

Mutation type

Frequency No. (%)a

Erlotinib Group

Gefinitib Group

18

G719Ab

1 (0.9%)

2 (1.2%)

G719S

0 (0)

1 (0.6%)

G719C

1(0.9%)

1 (0.6%)

19c

Del

43 (39.8%)

84 (49.1%)

Delins

6 (5.6%)

13 (7.6%)

20

T790M

0 (0)

0 (0)

S768I

0 (0)

0 (0)

21d

L858R

47 (43.5%)

59 (34.5%)

L861Q

10 (9.3%)

13 (7.6%)

  1. Abbreviations: del stands for deletion; delins stands for deletion-insertion
  2. a Two patients had double mutation
  3. b One patient had G719A and 19 del; one patient had G719A and L858R
  4. c Mutation of exon 21 in Erlotinib Group and Gefinitib Group (45.4% vs 56.7%, P = 0.067)
  5. d Mutation of exon 19 in Erlotinib Group and Gefinitib Group (52.8% vs 42.1%, P = 0.086)