Exons | Mutation type | Frequency No. (%)a
|
---|
Erlotinib Group | Gefinitib Group |
---|
18 | G719Ab
| 1 (0.9%) | 2 (1.2%) |
G719S | 0 (0) | 1 (0.6%) |
G719C | 1(0.9%) | 1 (0.6%) |
19c
| Del | 43 (39.8%) | 84 (49.1%) |
Delins | 6 (5.6%) | 13 (7.6%) |
20 | T790M | 0 (0) | 0 (0) |
S768I | 0 (0) | 0 (0) |
21d
| L858R | 47 (43.5%) | 59 (34.5%) |
L861Q | 10 (9.3%) | 13 (7.6%) |
-
Abbreviations: del stands for deletion; delins stands for deletion-insertion
-
a Two patients had double mutation
-
b One patient had G719A and 19 del; one patient had G719A and L858R
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c Mutation of exon 21 in Erlotinib Group and Gefinitib Group (45.4% vs 56.7%, P = 0.067)
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d Mutation of exon 19 in Erlotinib Group and Gefinitib Group (52.8% vs 42.1%, P = 0.086)