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Table 3 Relationship between expressions of 34 selected genes and Kaplan-Meier analysis

From: In search of druggable targets for GBM amino acid metabolism

  Enzymes for which …
higher expression is linked to poor survival lower expression is linked to poor survival expression is not correlated with survival
Enzymes with higher expression in GBM BCAT1 a
ASLa
LAP3
PIPOX a
GFPT2
DDO a
FAH
DDAH2
SHMT2
TYMS
SHMT1
TDO2
IDO1
Enzymes with expression as in normal brain CNDP2
GSS a
GLUL (GS)
PHGDH
SEPHS1
ABAT
ALT (GPT)
AGXT
ASNS
MTR
Enzymes with lower expression in GBM PRODH a
ASS1 a
AST (GOT1)
ASPA a
PAH
GLUD1/GLUD2
GAD1/GAD2
GLS
TH
  1. aSurvival curves for footnoted genes are shown in Fig. 3. Genes in bold have concordant protein (by IHC) and mRNA expression (by microarray)