Table 1 Overview inclusion and exclusion criteria ABLATIVE study

World Health Organization performance status 0–2

Legal incapacity

Females ≥ 50 years^b with cT1N0 tumor

Known BRCA gene mutation

Females ≥ 70 years with cT1-2^b _{(maximum 3 cm)} N0 tumor

MRI contra-indication

Tumor histology as assessed on biopsy:

Previous history of ipsilateral breast surgery and impaired cosmetic outcome, as assessed by the treating surgeon or radiation-oncologist.

- Ductal or ductolobular invasive carcinoma

- Estrogen receptor positivity

- HER2 receptor negative

Signs of extensive ductal carcinoma in situ on mammogram or histological biopsy.

Unifocal tumor

History of breast cancer

Tumor negative sentinel node procedure

Other type of malignancy within 5 years before breast cancer diagnosis^{a, b}

Adequate understanding of the Dutch language

Collagen synthesis disease