Table 3 Post-ABSCT treatment, toxicities and supportive care
Parameters | Overall cohort | Outpatient treatment | Hospital admission | P-value |
|---|---|---|---|---|
ABSCT number, n | 21 | 14 | 7 | / |
Treatment duration | ||||
Overall, days | 21 (18–31) | 21 (18–25) | 22 (19–31) | 0.38 |
Days as outpatient | 19 (8–25) | 21 (18–25) | 15 (8–19) | <0.01 |
Days as inpatient | 0 (0–18) | / | 5 (2–18) | <0.01 |
Reason for hospital admission, n (%) | / | |||
Neutropenic fever ≥72 h | 4 (19) | / | 4 (57) | |
Grade III stomatitis | 2 (10) | / | 2 (29) | |
Other | 1 (5) | / | 1 (14) | |
Toxicities | ||||
Stomatitis, n (%) | ||||
I | 17 (81) | 13 (93) | 4 (57) | |
II | 2 (10) | 1 (7) | 1 (14) | |
III | 2 (10) | 0 (0) | 2 (29) | |
Neutropenic fever | ||||
n, (%) | 14 (67) | 8 (57) | 6 (86) | 0.34 |
No. of days with fever | 3 (1–10) | 2 (1–7) | 4 (2–10) | 0.14 |
Diarrhoea, n (%) | 1 (5) | 1 (7) | 0 (0) | 1.00 |
Pulmonary infection, n (%) | 0 (0) | 0 (0) | 0 (0) | 1.00 |
Urinary tract infection, n (%) | 1 (5) | 0 (0) | 1 (14) | 0.33 |
Positive blood cultures, n (%) | ||||
Peripheral | 4 (19) | 1 (7) | 3 (43) | 0.09 |
Central | 0 (0) | 0 (0) | 0 (0) | 1.00 |
Port catheter infection, n (%) | ||||
Suspicion of | 3 (14) | 0 (0) | 3 (43) | 0.03 |
Proven | 0 (0) | 0 (0) | 0 (0) | 1.00 |
Port catheter explantation | 3 (14) | 0 (0) | 3 (43) | 0.03 |
SAE, n (%) | 0 (0) | 0 (0) | 0 (0) | 1.00 |
Support/Intervention | ||||
Red cell transfusion, n (%) | 6 (29) | 3 (21) | 3 (43) | 0.35 |
Platelet transfusion, n (%) | 15 (71) | 9 (64) | 6 (86) | 0.61 |
i.v. antibiotics | ||||
In case of neutropenic fever, n (%) | 14 (67) | 8 (57) | 6 (86) | 0.34 |
At subfebrile temperature, n (%) | 5 (24) | 4 (29) | 1 (14) | 0.62 |
Overall, days | 7 (4–14) | 7 (4–10) | 8 (4–14) | 0.61 |
Days as outpatient | 6 (1–10) | 7 (4–10) | 1 (0–6) | / |
Days as inpatient | 5 (2–14) | / | 5 (2–14) | / |