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Fig. 5 | BMC Cancer

Fig. 5

From: Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J

Fig. 5

Knockdown of CCNJ inhibited the cell invasion and migration in A549/DDP and SPC-A1/DDP cells. a Representative data of cell invasion assay and statistical graph in A549/DDP and SPC-A1/DDP cells transfected with siCCNJ or NCfor 6 h and then incubated with 1 μg/ml DDP for 24 h. b Representative data of cell migration assay and statistical graph in A549/DDP and SPC-A1/DDP cells transfected with siCCNJ or NC for 6 h and then incubated with 1 μg/ml DDP for 24 h. c The protein levels of CCNJ, P-gp, MRP1, LRP, P53 and cleaved Caspase-3were analyzed in A549/DDP and SPC-A1/DDP cells transfected with siCCNJ or NC for 6 h and then incubated with 1 μg/ml DDP for 48 h by Western blot. All data were expressed as mean value ± SD from 3 independent experiments. ***p < 0.001

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