PFS | OS | |||
---|---|---|---|---|
HR [95% CI] | P | HR [95% CI] | P | |
Age >60 years | 2.40 [0.90, 6.38] | 0.08 | 1.75 [0.37, 8.24] | 0.48 |
Ann Arbor stage IIIE-IVE | 5.65 [1.47, 21.80] | 0.01 | 9.55 [0.87, 104.27] | 0.06 |
LDH above normal | 2.16 [0.72, 6.48] | 0.17 | 3.60 [0.56, 23.12] | 0.18 |
ECOG >1 | 2.80 [0.93, 8.48] | 0.07 | 3.93 [0.78, 20.02] | 0.10 |
No. of extranodal sites >3 | 5.34 [1.40, 20.32] | 0.01 | 6.81 [1.09, 42.72] | 0.04 |
hypercalcemia | 1.76 [0.36, 8.54] | 0.48 | 6.92 [1.09, 44.01] | 0.04 |
AP above normal | 0.93 [0.29, 2.97] | 0.90 | 0.67 [0.13, 3.38] | 0.63 |
Multifocal bone lesions | 0.35 [0.11, 1.11] | 0.08 | 0.39 [0.08, 1.81] | 0.23 |
Rituximab | 0.16 [0.04, 0.62] | 0.008 | 0.23 [0.03, 1.80] | 0.16 |
Intensified chemotherapy | 0.50 [0.17, 1.49] | 0.21 | 0.62 [0.13, 2.96] | 0.55 |
Radiotherapy | 0.13 [0.04, 0.42] | 0.0006 | 0.01 [0.0006, 0.18] | 0.002 |