Skip to main content

Advertisement

Table 3 Comparison of the predictive accuracy of the prognostic models

From: Low CCL17 expression associates with unfavorable postoperative prognosis of patients with clear cell renal cell carcinoma

Models Overall survival Recurrence-free survival
C-index (95%CI) Coefficient (95%CI) P-value C-index (95%CI) Coefficient (95%CI) P-value
CCL17 0.615 (0.563–0.667)    0.612 (0.555–0.670)   
TNM 0.706 (0.652–0.760)    0.658 (0.601–0.719)   
TNM + CCL17 0.751 (0.699–0.803) 0.045 (0.016–0.074) 0.003† 0.717 (0.657–0.776) 0.018 (0.022–0.093) 0.002†
SSIGN 0.632 (0.580–0.685)    0.674 (0.617–0.731)   
SSIGN + CCL17 0.679 (0.620–0.738) 0.017 (0.014–0.079) 0.006† 0.720 (0.661–0.778) 0.045 (0.019–0.071) 0.001†
UISS 0.735 (0.688–0.781)    0.710 (0.658–0.762)   
UISS + CCL17 0.771 (0.724–0.818) 0.036 (0.017–0.055) <0.001† 0.752 (0.697–0.802) 0.047 (0.018–0.065) 0.001†
Nomogram 0.799 (0.754–0.844)    0.787 (0.735–0.840)   
Nomogram vs SSIGN   0.167 (0.118–0.215) <0.001‡   0.109 (0.064–0.155) <0.001‡
Nomogram vs UISS   0.064 (0.030–0.099) <0.001‡   0.073 (0.031–0.115) =0.001‡
  1. C-index and 95%CI were calculated from 1000 bootstrap samples to protect from overfitting
  2. C-index concordance index, CI confidence interval, SSIGN Mayo clinic stage, size, grade, and necrosis score, UISS UCLA Integrated Staging System
  3. †Compared the c-index with the original model without CCL17 expression data; ‡ Compared the c-index of nomogram with SSIGN/UISS stratification in different patient groups