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Fig. 6 | BMC Cancer

Fig. 6

From: Microparticles shed from multidrug resistant breast cancer cells provide a parallel survival pathway through immune evasion

Fig. 6

MPs shed from drug resistant cells mediate evasion of macrophage immunity: Overview of pathway: (1) MPs derived from resistant cancer cells bind to macrophage, stimulate a pro-inflammatory state (releasing cytokines-CKs), induce impaired macrophage chemotaxis and induce their engulfment by resistant or acquired resistant breast cancer cells. We propose this occurs through the Res-MP cargo which selectively packages P-gp, CD44 and HA relative to the (2) Sen-MP and D3-MPs

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