Fig. 2

Level of serum IgG antibody responses against recombinant extracellular Her-2/neu. a Kinetic of the antibody responses induced after 2, 3, and 4 immunizations with 30 μg of the hybrid peptide P467 conjugated to virosomes or CRM, are shown. b Comparison of the levels of the antibody responses induced after 3 immunizations with virosomal constructs expressing a mixture of single peptides (10 μg or 25 μg), virosomal constructs expressing the P467 peptide (15 μg or 30 μg), or the CRM-conjugated P467 administered together with Montanide (10 μg or 25 μg) is shown. The OD values are based on ELISA experiments as described in materials and methods. The statistical analysis was performed using ANOVA (two-way) and linear contrasts. Significant differences are denoted by asterisks