Skip to main content

Table 3 Metabolic characteristics of child survivors of leukemia and lymphoma according to treatment received at first assessment

From: Adipokines, insulin resistance, and adiposity as a predictors of metabolic syndrome in child survivors of lymphoma and acute lymphoblastic leukemia of a developing country

 

Treatment

Chemotherapy n = 32a

Chemotherapy plus radiotherapy n = 17b

Variables

Normal

Overweigth/Obese

Normal

Overweigth/Obese

 n: number (%)

17

15 (47)

12

5 (29)

 Sex (M)

12

12

9

4

 Current age (Y)

12.1 (8.1, 17.0)

12 (7.1, 17.0)

12.6 (7.1, 16.1)

12.1 (8.0, 17.1)

 Age at cancer diagnosis (Y)

6.0 (2.0, 13.0)

4.0 (2.0, 12.1)

6.5 (0.08, 12.1)

7 (1.0, 11.1)

 Time since completion of therapy (Y)

4.0 (2.0, 5.1)

4.0 (2.1, 5.1)

3.1 (3.0, 5.0)

4.0 (2.0, 5.0)

Weight (kg)

46.9 (18.1, 91.2)

48.9 (26.2, 102.9)

Height (cm)

148.4 (116.2, 178)

157.9 (123, 176.1)

 Diagnosis : ALL/Lymphoma

11/6

9/6

4/8

1/4

 Pubertal stage

 1

9

13*

5

3

 ≥ 2

8

2

7

2

MS Components

 WC (pc)

25 (10, 75)

90 (50, 100)*

50 (10, 90)

90 (75, 100)

 SBP (pc)

47 (3, 92)

53 (18, 93)

17 (2, 65)

47 (20, 99)

 DBP (pc)

76 (15, 94)

82 (57, 99)

75 (19, 96)

89 (39, 99)

 Triglicerydes (mg/dL)

76 (34, 149)

114 (50, 231)

72 (35, 164)

188 (148, 210)

 HDL-C (mg/dL)

42 (25, 84)

39.5 (26, 78)

42 (18, 64)

43 (18, 48)

 Glucose (mg/dL)

90 (75.5, 115.7)

91 (76, 105.7)

86 (74, 112.5)

93 (82, 99)

Others metabolic variables

 Insulin (μU/mL)

16.3 (9.1, 38.7)

24.9 (14.2, 35.3)*

20.5 (4.3, 50)

36.3 (19, 55)

 HOMA-IR

3.6 (1.7, 9.5)

5.5 (2.8, 8.2)*

4.3 (0.79, 13.9)

8.3 (4.7, 12.7)

 Adiponectin (μg/mL)

23 (1.3, 44.3)

22 (6.8, 70)

19.1 (11.7, 41.2)

16 (1.3, 27.6)

 Adiponectin per Kg fat (μg/mL/kg)

1.5 (0.39, 6.7)

1.2 (0.28, 4.9)

1.8 (0.51, 5.1)

0.75 (0.7, 1.8)

 Leptin ((μg/mL)

4.4 (2, 13.4)

18.2 (9.8, 30.9)*

7.4 (1.2, 19.0)

17.5 (13.5, 18.5)

 Leptin per Kg fat (μg/mL/kg)

0.49 (0.11, 3.0)

1.0 (0.34, 3.7)*

0.46 (0.16, 3.9)

0.72 (0.53, 1.31)

 Leptin to Adiponectin ratio

0.27 (0.08, 2.7)

0.98 (0.20, 3.0)*

0.33 (0.06, 0.76)

0.85 (0.67, 11.0)

 Body Fat (%)

23.4, (9.9, 36.2)

38.3 (32.0, 46.7)*

27.4 (8.3, 38.1)

37.1 (28.5, 40.2)

 VCAM (ng/mL)

1058 (561, 1727)

818 (425, 1730)

856 (586, 1207)

989 (490, 1697)

 ICAM (ng/mL)

459 (254, 661)

418 (294, 1079)

500 (265, 952)

398 (324, 598)

MS

 Yes/No

0/17

4/11

1/11

2/3

  1. Values are median (min, max); Abbreviations: MS Metabolic syndrome, HOMA-IR Homeostatic Model Assessment of Insulin Resistance, VCAM Vascular cell adhesion molecule, ICAM Intercellular adhesion molecule. aThree children of Chemotherapy group were excluded, because they were underweight; Data compared Mann–Whitney U-test and categorized data were analyzed using Fisher’s Test, *p value < 0.05; bIt was not possible to compare statistically (sample size)