Fig. 4
Prostate cancer associated mRNA analysis in MVs. a Venn diagram representing increased (red) and decreased (green) mRNA levels of prostate cancer (PCa) pathway genes in the LNCaP- and PC-3 MVs vs the PNT2 MVs (Ctrl). RT-qPCR data showing the statistically significant fold changes of particular genes in (b) LNCaP MVs vs Ctrl (c) PC-3 MVs vs Ctrl. Data are reported as the log2 of the fold change relative to the Ctrl. Fold-change cut-off =10. Bars represent the mean ± SEM of three independent experiments per group. *P <0.05, **P <0.01, ***P <0.001. d Venn diagram representing a summary the statistically significant mRNAs of the analyzed genes after comparison with the Ctrl, exclusively present in LNCaP MVs and PC-3 MVs. The mRNAs that were significantly common for both samples are also represented